The biology of lipid droplet-bound mitochondria.
Adipose tissue
Lipid droplets
Lipotoxicity
Miochondria
Triacylglycerides
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
04
12
2019
revised:
17
04
2020
accepted:
18
04
2020
pubmed:
25
5
2020
medline:
12
8
2021
entrez:
25
5
2020
Statut:
ppublish
Résumé
Proper regulation of cellular lipid storage and oxidation is indispensable for the maintenance of cellular energy homeostasis and health. Mitochondrial function has been shown to be a main determinant of functional lipid storage and oxidation, which is of particular interest for the adipose tissue, as it is the main site of triacylglyceride storage in lipid droplets (LDs). Recent studies have identified a subpopulation of mitochondria attached to LDs, peridroplet mitochondria (PDM) that can be separated from cytoplasmic mitochondria (CM) by centrifugation. PDM have distinct bioenergetics, proteome, cristae organization and dynamics that support LD build-up, however their role in adipose tissue biology remains largely unexplored. Therefore, understanding the molecular basis of LD homeostasis and their relationship to mitochondrial function and attachment in adipocytes is of major importance.
Identifiants
pubmed: 32446655
pii: S1084-9521(18)30311-2
doi: 10.1016/j.semcdb.2020.04.013
pmc: PMC8019155
mid: NIHMS1683718
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-64Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026914
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099618
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
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