BMP gene delivery for skeletal tissue regeneration.

Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins / genetics Bone Regeneration / genetics Cartilage Genetic Therapy Quality of Life Tissue Engineering
Bone morphogenetic protein Gene therapy Tissue engineering

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
08 2020
Historique:
received: 09 03 2020
revised: 19 05 2020
accepted: 20 05 2020
pubmed: 25 5 2020
medline: 22 6 2021
entrez: 25 5 2020
Statut: ppublish

Résumé

Musculoskeletal disorders are common and can be associated with significant morbidity and reduced quality of life. Current treatments for major bone loss or cartilage defects are insufficient. Bone morphogenetic proteins (BMPs) are key players in the recruitment and regeneration of damaged musculoskeletal tissues, and attempts have been made to introduce the protein to fracture sites with limited success. In the last 20 years we have seen a substantial progress in the development of various BMP gene delivery platforms for several conditions. In this review we cover the progress made using several techniques for BMP gene delivery for bone as well as cartilage regeneration, with focus on recent advances in the field of skeletal tissue engineering. Some methods have shown success in large animal models, and with the global trend of introducing gene therapies into the clinical setting, it seems that the day in which BMP gene therapy will be viable for clinical use is near.

Identifiants

DOI: 10.1016/j.bone.2020.115449 PMID: 32447073 PMC: PMC7354211
pubmed: 32447073
pii: S8756-3282(20)30229-5
doi: 10.1016/j.bone.2020.115449
pmc: PMC7354211
mid: NIHMS1600210
pii:
doi:

Substances chimiques

Bone Morphogenetic Protein 2 0
Bone Morphogenetic Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115449

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE019902
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB026094
Pays : United States

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest G.P. and D.G. are shareholders in GamlaStem Medical Inc.

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Auteurs

Maxim Bez (M)

Medical Corps, Israel Defense Forces, Israel; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: maxim.bez@mail.huji.ac.il.

Gadi Pelled (G)

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: pelledg@cshs.org.

Dan Gazit (D)

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: danga@ekmd.huji.ac.il.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Protéine morphogénétique osseuse de type 2 › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › BMP gene delivery for skeletal tissue regeneration.
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › BMP gene delivery for skeletal tissue regeneration.