Triterpene glycosides from Silene odontopetala.
Caryophyllaceae
NMR analysis
Oleanane-type saponins
Silene odontopetala
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
18
10
2019
revised:
11
05
2020
accepted:
12
05
2020
pubmed:
25
5
2020
medline:
4
8
2020
entrez:
25
5
2020
Statut:
ppublish
Résumé
Silene species are known for their use in traditional medicine in treating several diseases. To the authors' knowledge there is no report on the chemical composition of S. odontopetala. Therefore, the phytochemical investigation of the methanol extract of S. odontopetala was carried out, leading to the isolation of six undescribed oleanane-type glycosides along with the known saponin azukisaponin IV. Their structures were elucidated by the analysis of 1D and 2D-NMR experiments, along with mass spectrometry analysis. The cytotoxic activity of oleanane-type saponins was evaluated against a small panel of cancer cell lines, including PC-3 (prostate carcinoma cells), MCF-7 (breast cancer cells), A549 (alveolar basal carcinoma cells), and HeLa (cervical carcinoma cells). Furthermore, the activity of isolated compounds against a normal cell line HEK-293, used for assessing their cytotoxicity, was evaluated.
Identifiants
pubmed: 32447090
pii: S0031-9422(19)31034-9
doi: 10.1016/j.phytochem.2020.112404
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Glycosides
0
Saponins
0
Triterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112404Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.