Dental amalgams and risk of gestational hypertension in the MIREC study.
Dental disorders
Environmental chemicals
Obstetrics complications
Perinatal
Preeclampsia
Pregnancy
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
19
09
2019
accepted:
25
04
2020
pubmed:
25
5
2020
medline:
28
5
2021
entrez:
25
5
2020
Statut:
ppublish
Résumé
The potential association between the presence or replacement of dental amalgams and gestational hypertension (GH) is unclear. To assess the association between the presence or replacement of dental amalgams and the risk of GH in a prospective cohort study. We assessed dental amalgam status (presence or replacement), blood mercury concentrations, and measured blood pressure (BP) in 1817 pregnant women recruited in 10 Canadian cities. BP was assessed in each trimester of pregnancy and mercury concentrations in 1st and 3rd trimesters. Logistic regression analysis was performed to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the associations between dental amalgam status and GH. Concurrent measures with systolic BP (SBP) and diastolic BP (DBP) were assessing through linear generalized estimating equations. Dental amalgam status was weakly statistically correlated with mercury concentrations but there was no evidence of an association with GH in women having 1-4 (aOR = 1.31 (0.92, 1.85)) or ≥ 5 dental amalgams (aOR = 1.32 (0.86, 2.04)), compared to women without amalgam reported at first trimester. Dental amalgam replacement reported in the first or third trimester was similarly not associated with GH (aOR = 0.75 (0.40, 1.42) and 0.73 (0.39, 1.34), respectively) but with SBP (beta = -1.58 (-2.95, -0.02)). We found weak correlations between dental amalgams and blood mercury among pregnant women. However, the presence of dental amalgams or their replacement was not associated with GH but with decreased SBP for the replacement. Further studies are required.
Sections du résumé
BACKGROUND
BACKGROUND
The potential association between the presence or replacement of dental amalgams and gestational hypertension (GH) is unclear.
OBJECTIVE
OBJECTIVE
To assess the association between the presence or replacement of dental amalgams and the risk of GH in a prospective cohort study.
METHODS
METHODS
We assessed dental amalgam status (presence or replacement), blood mercury concentrations, and measured blood pressure (BP) in 1817 pregnant women recruited in 10 Canadian cities. BP was assessed in each trimester of pregnancy and mercury concentrations in 1st and 3rd trimesters. Logistic regression analysis was performed to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the associations between dental amalgam status and GH. Concurrent measures with systolic BP (SBP) and diastolic BP (DBP) were assessing through linear generalized estimating equations.
RESULTS
RESULTS
Dental amalgam status was weakly statistically correlated with mercury concentrations but there was no evidence of an association with GH in women having 1-4 (aOR = 1.31 (0.92, 1.85)) or ≥ 5 dental amalgams (aOR = 1.32 (0.86, 2.04)), compared to women without amalgam reported at first trimester. Dental amalgam replacement reported in the first or third trimester was similarly not associated with GH (aOR = 0.75 (0.40, 1.42) and 0.73 (0.39, 1.34), respectively) but with SBP (beta = -1.58 (-2.95, -0.02)).
CONCLUSION
CONCLUSIONS
We found weak correlations between dental amalgams and blood mercury among pregnant women. However, the presence of dental amalgams or their replacement was not associated with GH but with decreased SBP for the replacement. Further studies are required.
Identifiants
pubmed: 32447273
pii: S2210-7789(20)30054-4
doi: 10.1016/j.preghy.2020.04.015
pii:
doi:
Substances chimiques
Dental Amalgam
8049-85-2
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-89Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.