Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old.
Adolescent
Biomarkers
/ blood
Blood Group Antigens
Child
Child, Preschool
Creatinine
/ blood
Cystatin C
/ blood
Female
Glomerular Filtration Rate
/ physiology
Healthy Volunteers
Humans
Infant
Infant, Newborn
Kidney Function Tests
/ statistics & numerical data
Male
Models, Statistical
Reference Values
Sensitivity and Specificity
Sex Factors
Continuous reference intervals
Kidney function
Paediatric
Serum cystatin C
Journal
Pediatric nephrology (Berlin, Germany)
ISSN: 1432-198X
Titre abrégé: Pediatr Nephrol
Pays: Germany
ID NLM: 8708728
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
10
02
2020
accepted:
12
05
2020
revised:
16
04
2020
pubmed:
25
5
2020
medline:
3
7
2021
entrez:
25
5
2020
Statut:
ppublish
Résumé
Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC. The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs. A total of 378 samples with equal numbers of males and females were analysed for serum CysC. No outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots. This study established continuous paediatric reference intervals (RIs) for serum CysC in healthy term neonates and children. The continuous RIs generated from this study show age-based dynamic changes as well as blood group and gender-specific differences for serum CysC. Graphical abstract.
Sections du résumé
BACKGROUND
Serum cystatin C (CysC) is a promising biomarker of kidney function, which has higher accuracy and sensitivity when compared with creatinine. To better utilize serum CysC in clinical practice, this study aimed to establish continuous paediatric reference intervals (RIs) for serum CysC.
METHODS
The study subjects consisted of healthy term neonates and children aged 30 days to 18 years. Venous blood samples were collected and serum CysC levels were measured using the immunoturbidimetric measurement principle. Fractional polynomial regression model and quantile regression was applied in the statistical analysis to generate continuous RIs.
RESULTS
A total of 378 samples with equal numbers of males and females were analysed for serum CysC. No outliers were found in this analysis. The continuous RIs are presented as equations and graphical scatterplots.
CONCLUSIONS
This study established continuous paediatric reference intervals (RIs) for serum CysC in healthy term neonates and children. The continuous RIs generated from this study show age-based dynamic changes as well as blood group and gender-specific differences for serum CysC. Graphical abstract.
Identifiants
pubmed: 32447504
doi: 10.1007/s00467-020-04612-5
pii: 10.1007/s00467-020-04612-5
doi:
Substances chimiques
Biomarkers
0
Blood Group Antigens
0
CST3 protein, human
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM