The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis.
Journal
European journal of dentistry
ISSN: 1305-7456
Titre abrégé: Eur J Dent
Pays: Germany
ID NLM: 101303672
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
pubmed:
25
5
2020
medline:
25
5
2020
entrez:
25
5
2020
Statut:
ppublish
Résumé
Liquid coconut shell smoke (LC-SS) is used in natural food preservation for a long history. The purpose of this study was to analyze the role of LC-SS in macrophage responses during diabetic oral ulcer healing as medication. Oral ulcers were induced in the labial lower mucosa of the research subjects using a round steel blade following diabetic induction by means of alloxan. Twenty-four diabetic Wistar rats presenting oral ulcers were divided into two groups, a test group, which was given topical treatment of LC-SS and a control group, which was given benzydamine hydrochloride (BHCl). The role of LC-SS in macrophages was assessed by means of immunohistochemistry for nuclear factor kappa B (NF-κB) and tumor necrosis factor-α (TNF-α) expression. LC-SS increased macrophages compared with BHCl ( LC-SS has a stronger effect compared with BHCl on diabetic oral ulcer healing by increasing macrophage response to produce TNF-α while decreasing NF-κB expression.
Identifiants
pubmed: 32447753
doi: 10.1055/s-0040-1712776
pmc: PMC7440958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
410-414Subventions
Organisme : 1408/UN3/2019
ID : the Faculty of Dental Medicine - Universitas Airlangga, Surabaya, Indonesia 2019
Déclaration de conflit d'intérêts
None declared.
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