Genetic stratification of depression in UK Biobank.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
24 05 2020
24 05 2020
Historique:
received:
15
10
2019
accepted:
30
04
2020
revised:
28
04
2020
entrez:
26
5
2020
pubmed:
26
5
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.
Identifiants
pubmed: 32448866
doi: 10.1038/s41398-020-0848-0
pii: 10.1038/s41398-020-0848-0
pmc: PMC7246256
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
163Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1087889
Pays : International
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1078901
Pays : International
Organisme : Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
ID : 27404
Pays : International
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S015132/1
Pays : United Kingdom
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/N015746/1
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 104036/Z/14/Z
Pays : International
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/S0151132
Pays : International
Organisme : Wellcome Trust (Wellcome)
ID : 213674/Z/18/Z
Pays : International
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