Effects of Intranasal Epinephrine on Cerebrospinal Fluid Epinephrine Pharmacokinetics, Nasal Mucosa, Plasma Epinephrine Pharmacokinetics, and Cardiovascular Changes.
Administration, Intranasal
/ adverse effects
Anaphylaxis
/ drug therapy
Animals
Area Under Curve
Cardiovascular System
/ drug effects
Cerebrospinal Fluid
/ metabolism
Dogs
Drug Evaluation, Preclinical
Epinephrine
/ administration & dosage
Female
Heart Rate
/ drug effects
Humans
Injections, Intramuscular
Male
Models, Animal
Nasal Mucosa
/ diagnostic imaging
Allergy
anaphylaxis
epinephrine
intranasal
pharmacokinetics (5/5)
Journal
Pharmaceutical research
ISSN: 1573-904X
Titre abrégé: Pharm Res
Pays: United States
ID NLM: 8406521
Informations de publication
Date de publication:
24 May 2020
24 May 2020
Historique:
received:
12
11
2019
accepted:
21
04
2020
entrez:
26
5
2020
pubmed:
26
5
2020
medline:
16
3
2021
Statut:
epublish
Résumé
We aimed to assess intranasal (IN) epinephrine effects on cerebrospinal fluid (CSF) absorption, nasal mucosa quality, plasma epinephrine pharmacokinetics (PK), and cardiovascular changes in dogs. CSF epinephrine concentration was measured and nasal mucosa quality was evaluated after IN epinephrine 4 mg and one or two 4 mg doses (21 min apart), respectively. Maximum plasma concentration [C After epinephrine IN, there were no changes in CSF epinephrine or nasal mucosa. C Epinephrine IN did not alter CSF epinephrine or nasal tissue and had similar cardiovascular effects as epinephrine IM. Epinephrine IN rapidly increased plasma epinephrine concentration versus epinephrine IM.
Identifiants
pubmed: 32448925
doi: 10.1007/s11095-020-02829-5
pii: 10.1007/s11095-020-02829-5
doi:
Substances chimiques
Epinephrine
YKH834O4BH
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM