Trichophyton indotineae sp. nov.: A New Highly Terbinafine-Resistant Anthropophilic Dermatophyte Species.
Dermatophytosis
Terbinafine resistance
Tinea corporis
Trichophyton indotineae
Journal
Mycopathologia
ISSN: 1573-0832
Titre abrégé: Mycopathologia
Pays: Netherlands
ID NLM: 7505689
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
11
2019
accepted:
12
05
2020
pubmed:
26
5
2020
medline:
4
9
2021
entrez:
26
5
2020
Statut:
ppublish
Résumé
In this report, we describe the first isolation of two highly terbinafine (TRF)-resistant Trichophyton interdigitale-like strains from a Nepali patient and an Indian patient with tinea corporis in Japan. These strains (designated NUBS19006 and NUBS19007) exhibited a TRF minimal inhibitory concentration (MIC) of > 32 mg/L and contained a missense mutation (Phe397Leu) in squalene epoxidase (SQLE) gene. The internal transcribed spacer (ITS) region sequences amplified from the isolates (NUBS19006 and NUBS19007) were 99.5% identical to Japanese isolates of T. interdigitale and T. interdigitale strain CBS 428.63. The homology of region sequences were also 97.6% identical to T. mentagrophytes strain CBS 318.56. Moreover, the ITS sequences amplified from the isolates were 100% identical to highly TRF-resistant strains of T. interdigitale, which were isolated in Delhi, India, and harbored mutations in SQLE. The urease test on Christensen's urease agar was positive for T. mentagrophytes and T. interdigitale after 7 days of incubation. On the other hand, the type strain of T. rubrum CBS 100081
Identifiants
pubmed: 32449054
doi: 10.1007/s11046-020-00455-8
pii: 10.1007/s11046-020-00455-8
doi:
Substances chimiques
Antifungal Agents
0
Squalene Monooxygenase
EC 1.14.14.17
Terbinafine
G7RIW8S0XP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
947-958Références
Kwon-Chung KJ, Bennett EJ. Dermatophytoses. In: Medical mycology, Philadelphia: Lea & Febiger, 1992;105–161 and 816–826.
Reiss E, Shadomy HJ, Lyon IIIGM. Dermatophytosis. In: Fundamental medical mycology, New Jersey: Wiley; 2012; 527–566.
Singh A, Masih A, Khurana A, Singh PK, Gupta M, Hagen F, Meis JF, Chowdhary A. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses. 2018;61:477–84.
doi: 10.1111/myc.12772
Singh A, Masih A, Monroy-Nieto J, Singh PK, Bowers J, Travis J, Khurana A, Engelthaler DM, Meis JF, Chowdhary A. A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: genomic insights and resistance profile. Fungal Genet Biol. 2019. https://doi.org/10.1016/j.fgb.2019.103266 .
doi: 10.1016/j.fgb.2019.103266
pubmed: 31491507
Friedman DZP, Schwartz IS. J Fungi (Basel). 2019;2:E67. https://doi.org/10.3390/jof5030067 .
doi: 10.3390/jof5030067
Kakurai M, Kazutoshi H, Maeda T, Hiruma J, Kano R, Demitsu T. A case of tinea corporis due to terbinafine-resistant Trichophyton interdigitale. J Dermatol. 2020. https://doi.org/10.1111/1346-8138.15243 .
doi: 10.1111/1346-8138.15243
pubmed: 32748954
Kimura U, Hiruma M, Kano R, Matsumoto T, Noguchi H, Takamori K, Suga Y. Caution-and-warning: arrival of terbinafine-resistant Trichophyton interdigitale of the Indian genotype, isolated from extensive dermatophytosis, in Japan. J Dermatol. 2020. https://doi.org/10.1111/1346-8138.15300 .
doi: 10.1111/1346-8138.15300
pubmed: 33161603
Kano R, Kawasaki M, Mochizuki T, Hiruma M, Hasegawa A. Mating genes of the Trichophyton mentagrophytes complex. Mycopathologia. 2012;173:103–12.
doi: 10.1007/s11046-011-9487-6
Hinrikson HP, Hurst SF, Lott TJ, Warnock DW, Morrison CJ. Assessment of ribosomal large-subunit D1–D2, internal transcribed spacer 1, and internal transcribed spacer 2 regions as target for molecular identification of medically important Aspergillus species. J Clin Microbiol. 2005;43:2092–103.
doi: 10.1128/JCM.43.5.2092-2103.2005
Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucl Acid Res. 1994;22:4673–80.
doi: 10.1093/nar/22.22.4673
Page RDM. TREEVIEW: an application to display phylogenetic trees on personal computers. Comput Appl Biosci. 1996;12:357–8.
pubmed: 8902363
Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evolution. 1985;39:783–91.
doi: 10.1111/j.1558-5646.1985.tb00420.x
CLSI. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard 2nd ed. CLSI document M38-A2. Clinical Laboratory Standards Institute. Philadelphia: Wayne; 2008.
Itoi S, Kano R, Hasegawa A, Hasegawa A, Kamata H. In vitro activities of antifungal agents against clinical isolates of dermatophytes from animals. J Vet Med Sci. 2012;74:1067–9.
doi: 10.1292/jvms.12-0057
Hiruma J, Kitagawa H, Noguchi H, Kano R, Hiruma M, Kamata H, Harada K. Terbinafine-resistant strain of Trichophyton interdigitale strain isolated from a tinea pedis patient. J Dermatol. 2019;46:351–3.
doi: 10.1111/1346-8138.14809
Ellis D, Davis S, Alexiou H, Handke R, Bartley R. Descriptions of medical fungi. 2nd ed. South Australia: Nexus Print Solutions; 2007.
Kane J, Summerbell R, Sigler L, Krajden S, Land G. Laboratory handbook of dermatophytes: a clinical guide and laboratory manual of dermatophytes and other filamentous fungi from skin, hair, and nails. Belmont: Star Publishing Company; 1997.
Hironaga M, Watanabe S. Mating behavier of 334 Japanese isolaties of Trichophyton mentagrophytes in relation to their ecological status. Mycologia. 1980;72:1159–70.
doi: 10.1080/00275514.1980.12021297
de Hoog GS, Dukik K, Monod M, Packeu A, Stubbe D, Hendrickx M, Kupsch C, Stielow JB, Freeke J, Göker M, Rezaei-Matehkolaei A, Mirhendi H, Gräser Y. Toward a novel multilocus phylogenetic taxonomy for the dermatophytes. Mycopathologia. 2017;182:5–31.
doi: 10.1007/s11046-016-0073-9
Chaturvedi V, de Hoog GS. Onygenalean fungi as major human and animal pathogens. Mycopathologia. 2020;185:1–8.
pubmed: 32002816
Kandemir H, Dukik K, Hagen F, Ilkit M, Gräser Y, de Hoog GS. Polyphasic discrimination of trichophyton tonsurans and t equinum from humans and horses. Mycopathologia. 2020;185:113–22.
pubmed: 31278475