Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation.
bond dissociation
cancer photoimmunotherapy
density functional calculation
near-infrared dyes
radical anions
silicon phthalocyanine
Journal
ChemPlusChem
ISSN: 2192-6506
Titre abrégé: Chempluschem
Pays: Germany
ID NLM: 101580948
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
28
04
2020
revised:
01
05
2020
pubmed:
26
5
2020
medline:
24
6
2021
entrez:
26
5
2020
Statut:
ppublish
Résumé
Ligand release from IR700, a silicon phthalocyanine dye used in near-infrared (NIR) photoimmunotherapy, initiates cancer cell death after NIR absorption, although its photochemical mechanism has remained unclear. This theoretical study reveals that the direct Si-ligand dissociation by NIR light is difficult to activate because of the high dissociation energy even in excited states, i. e., >1.30 eV. Instead, irradiation generates the IR700 radical anion, leading to acid-base reactions with nearby water molecules (i. e., calculated pK
Identifiants
pubmed: 32449613
doi: 10.1002/cplu.202000338
doi:
Substances chimiques
Anions
0
Indoles
0
Organosilicon Compounds
0
Photosensitizing Agents
0
silicon phthalocyanine
135719-28-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1959-1963Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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