Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.
behavior
brain
neuroendocrine
nuclear receptor corepressor (NCOR)
steroid receptor coactivator (SRC)
Journal
Endocrinology
ISSN: 1945-7170
Titre abrégé: Endocrinology
Pays: United States
ID NLM: 0375040
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
received:
06
04
2020
accepted:
20
05
2020
pubmed:
26
5
2020
medline:
5
1
2021
entrez:
26
5
2020
Statut:
ppublish
Résumé
Nuclear receptor coactivators (NCOAs) and corepressors (NCORs) bind to nuclear hormone receptors in a ligand-dependent manner and mediate the transcriptional activation or repression of the downstream target genes in response to hormones, metabolites, xenobiotics, and drugs. NCOAs and NCORs are widely expressed in the mammalian brain. Studies using genetic animal models started to reveal pivotal roles of NCOAs/NCORs in the brain in regulating hormonal signaling, sexual behaviors, consummatory behaviors, exploratory and locomotor behaviors, moods, learning, and memory. Genetic variants of NCOAs or NCORs have begun to emerge from human patients with obesity, hormonal disruption, intellectual disability, or autism spectrum disorders. Here we review recent studies that shed light on the function of NCOAs and NCORs in the central nervous system.
Identifiants
pubmed: 32449767
pii: 5843759
doi: 10.1210/endocr/bqaa083
pmc: PMC7351129
pii:
doi:
Substances chimiques
Co-Repressor Proteins
0
Nuclear Receptor Coactivators
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P01 DK113954
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115761
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA126752
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111436
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027544
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA215591
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056338
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117281
Pays : United States
Informations de copyright
© Endocrine Society 2020.
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