Daucosterol from Crateva adansonii DC (Capparaceae) reduces 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Wistar rats.
9,10-Dimethyl-1,2-benzanthracene
/ toxicity
Animals
Antineoplastic Agents, Phytogenic
/ isolation & purification
Antioxidants
/ metabolism
Capparaceae
/ chemistry
Carcinogens
/ toxicity
Dose-Response Relationship, Drug
Female
Mammary Neoplasms, Experimental
/ chemically induced
Molecular Structure
Plant Bark
/ chemistry
Rats
Rats, Wistar
Sitosterols
/ isolation & purification
CA 15-3
DMBA
antioxidant
biomarker
daucosterol
mammary tumor
Journal
Environmental toxicology
ISSN: 1522-7278
Titre abrégé: Environ Toxicol
Pays: United States
ID NLM: 100885357
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
20
02
2020
revised:
29
04
2020
accepted:
08
05
2020
pubmed:
26
5
2020
medline:
9
10
2020
entrez:
26
5
2020
Statut:
ppublish
Résumé
This study aimed to evaluate the in vivo anticancer effects of daucosterol which was earlier reported to possess in vitro anticancer effects. Breast tumor was induced in 30 rats using the environmental carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) while 6 control rats received olive oil (NOR). Animals with palpable tumors were randomized into five groups (n = 6) each as follows: negative control group treated with the vehicle (DMBA); positive control group treated with 5 mg/kg BW doxorubicin (DOXO + DMBA); three groups treated with daucosterol at doses of 2.5, 5, and 10 mg/kg BW (DAU + DMBA). Treatment lasted 28 days afterward, tumor (mass, volume, cancer antigen [CA] 15-3 level and histoarchitecture), hematological and toxicological parameters were examined. The tumor volume gradually increased in the DMBA group during the 28 days, with a tumor volume gain of ∼390 cm
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Carcinogens
0
Sitosterols
0
9,10-Dimethyl-1,2-benzanthracene
57-97-6
lyoniside
U45VN859W3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1136Subventions
Organisme : The Academy of Sciences for the Developing World
ID : 17-344 RG/BIO/AF/AC_I-FR3240297739
Informations de copyright
© 2020 Wiley Periodicals LLC.
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