Potential classification of chemical immunologic response based on gene expression profiles.
Administration, Cutaneous
Allergens
/ administration & dosage
Animals
Anti-Infective Agents
/ administration & dosage
Asthma, Occupational
/ blood
Calgranulin A
/ genetics
Cytokines
/ genetics
Dermatitis, Allergic Contact
/ blood
Dermatitis, Occupational
/ blood
Disease Models, Animal
Female
Gene Expression Profiling
Gene Expression Regulation
/ drug effects
Humans
Irritants
/ adverse effects
Lung
/ drug effects
Mice
Occupational Exposure
/ adverse effects
Skin
/ drug effects
Th2 Cells
/ drug effects
Thymic Stromal Lymphopoietin
Immune
antimicrobials
gene expression
skin
Journal
Journal of immunotoxicology
ISSN: 1547-6901
Titre abrégé: J Immunotoxicol
Pays: England
ID NLM: 101201960
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
entrez:
26
5
2020
pubmed:
26
5
2020
medline:
17
6
2021
Statut:
ppublish
Résumé
Occupational immune diseases are a serious public health burden and are often a result of exposure to low molecular weight (LMW) chemicals. The complete immunological mechanisms driving these responses are not fully understood which has made the classification of chemical allergens difficult. Antimicrobials are a large group of immunologically-diverse LMW agents. In these studies, mice were dermally exposed to representative antimicrobial chemicals (sensitizers: didecyldimethylammonium chloride (DDAC),
Identifiants
pubmed: 32449871
doi: 10.1080/1547691X.2020.1758855
pmc: PMC7673648
mid: NIHMS1639316
doi:
Substances chimiques
Allergens
0
Anti-Infective Agents
0
Calgranulin A
0
Cytokines
0
Irritants
0
S100a8 protein, mouse
0
Thymic Stromal Lymphopoietin
GT0IL38SP4
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
122-134Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
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