Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats.
Animals
Biomarkers
Biopsy
Chemical Phenomena
Cytokines
/ metabolism
Disease Models, Animal
Epidermal Growth Factor
/ metabolism
Ethanol
/ adverse effects
Fungal Polysaccharides
/ chemistry
Gastric Mucosa
/ drug effects
Hericium
/ chemistry
Immunohistochemistry
Male
Protective Agents
/ chemistry
Rats
Stomach Ulcer
/ drug therapy
Gastric ulcer
Gastroprotective activity
Hericium erinaceus
Purified polysaccharide
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Sep 2020
15 Sep 2020
Historique:
received:
09
03
2020
revised:
17
05
2020
accepted:
19
05
2020
pubmed:
26
5
2020
medline:
20
3
2021
entrez:
26
5
2020
Statut:
ppublish
Résumé
The β-glucan H6PC20 (Mw: 2390 kDa) and α-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and corresponding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, macroscopic and histological evaluation of gastric mucosa was improved significantly. The defense and repair factors (EGF, bFGF and PGE
Identifiants
pubmed: 32450327
pii: S0141-8130(20)33317-1
doi: 10.1016/j.ijbiomac.2020.05.163
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Fungal Polysaccharides
0
Protective Agents
0
Ethanol
3K9958V90M
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
948-956Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no competing financial interests.