Trabecular bone score and transilial bone trabecular histomorphometry in type 1 diabetes and healthy controls.
Bone
DXA
Diabetes
Histomorphometry
Micro-CT
Trabecular bone score
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
06
02
2020
revised:
24
04
2020
accepted:
20
05
2020
pubmed:
26
5
2020
medline:
22
6
2021
entrez:
26
5
2020
Statut:
ppublish
Résumé
Patients with type 1 Diabetes Mellitus (T1DM) have an increased risk of fracture. Little is known about the microarchitecture of trabecular bone in T1DM, which may account for some of the increased risk. We report here a secondary analysis comparing Trabecular Bone Score (TBS) derived from DXA to 2-D histomorphometric and 3-D micro-computerized tomography (CT) variables obtained from iliac biopsies in 83 subjects (29 T1DM and 54 controls). The transilial bone biopsy specimens were fixed, embedded and scanned using a desktop micro-CT at 16 μm resolution. They were then sectioned and quantitative histomorphometry was performed. TBS of the anterior/posterior (AP) spine was obtained by re-analysis of AP lumbar spine DXA images. Overall, there were no differences in TBS, histomorphometry or micro-CT measurements between T1DM and controls. There was a significant association between TBS and 2-D BV/TV using multivariable linear regression after adjusting for group, age and gender. For every 1 unit increase in 2-D BV/TV, TBS increases by 0.0036 units after adjusting for group, gender and age. In conclusion, T1DM does not result in abnormal TBS, histomorphometric or micro-CT variables in young T1DM patients in the absence of diabetic complications. TBS is a good surrogate measure for trabecular microarchitecture.
Identifiants
pubmed: 32450341
pii: S8756-3282(20)30231-3
doi: 10.1016/j.bone.2020.115451
pmc: PMC7354208
mid: NIHMS1600585
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115451Subventions
Organisme : NIAMS NIH HHS
ID : K23 AR055542
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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