Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet.
Alzheimer’s disease
DHA
Lipid profile
Phosphatidylcholine
Phosphatidylserine
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
25 May 2020
25 May 2020
Historique:
received:
23
11
2019
accepted:
31
03
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
25
3
2021
Statut:
epublish
Résumé
Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dementia animals. SAMP8 mice was fed with different diet patterns for 2 months, including high-fat diet and low-fat diet. After intervention with DHA-PC and DHA-PS for another 2 months, the lipid profile in cerebral cortex was determined by lipidomics in dementia mice. High-fat diet could significantly decrease the levels of DHA-containing PS/pPE, DPA-containing PS, and AA-containing PE, which might exhibit the potential of lipid biomarkers for the prevention and diagnosis of AD. Notably, DHA-PC and DHA-PS remarkably recovered the lipid homeostasis in dementia mice. These might provide a potential novel therapy strategy and direction of dietary intervention for patients with cognitive decline. DHA-PC and DHA-PS could recover the content of brain DHA-containing PS and pPE in SAMP8 mice fed with high-fat diet.
Sections du résumé
BACKGROUND
BACKGROUND
Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dementia animals.
METHODS
METHODS
SAMP8 mice was fed with different diet patterns for 2 months, including high-fat diet and low-fat diet. After intervention with DHA-PC and DHA-PS for another 2 months, the lipid profile in cerebral cortex was determined by lipidomics in dementia mice.
RESULTS
RESULTS
High-fat diet could significantly decrease the levels of DHA-containing PS/pPE, DPA-containing PS, and AA-containing PE, which might exhibit the potential of lipid biomarkers for the prevention and diagnosis of AD. Notably, DHA-PC and DHA-PS remarkably recovered the lipid homeostasis in dementia mice. These might provide a potential novel therapy strategy and direction of dietary intervention for patients with cognitive decline.
CONCLUSIONS
CONCLUSIONS
DHA-PC and DHA-PS could recover the content of brain DHA-containing PS and pPE in SAMP8 mice fed with high-fat diet.
Identifiants
pubmed: 32450867
doi: 10.1186/s12944-020-01253-3
pii: 10.1186/s12944-020-01253-3
pmc: PMC7249346
doi:
Substances chimiques
Phosphatidylcholines
0
Phosphatidylserines
0
Plasmalogens
0
phosphatidal ethanolamines
0
Docosahexaenoic Acids
25167-62-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104Subventions
Organisme : National Key R&D Program of China
ID : 2018YFD0901103
Organisme : National Natural Science Foundation of China
ID : 31901688
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2019QC004
Organisme : National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers
ID : U1606403
Organisme : Laboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology
ID : LMDBKF201807
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