Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.
Animals
Down-Regulation
/ genetics
Female
Gene Expression Regulation
/ radiation effects
Homeostasis
/ genetics
Intraocular Pressure
/ genetics
Mice, Inbred DBA
Microglia
/ metabolism
Monocytes
/ metabolism
Ocular Hypertension
/ genetics
Optic Disk
/ metabolism
Phagocytosis
/ genetics
Phenotype
RNA, Messenger
/ genetics
Transcriptome
/ genetics
Up-Regulation
/ genetics
DBA/2 J
Glaucoma
Microglia
Mitochondria
Neuroinflammation
Optic nerve head
RNA-sequencing
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
25 05 2020
25 05 2020
Historique:
received:
22
12
2019
accepted:
13
04
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
5
6
2021
Statut:
epublish
Résumé
Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic nerve head following ocular hypertension. Microglia and infiltrating monocytes are likely candidates to drive these neuroinflammatory insults. However, the exact molecular identity / transcriptomic profile of microglia following ocular hypertensive insults is unknown. To elucidate the molecular identity of microglia after long-term exposure to ocular hypertension, we used a mouse model of glaucoma (DBA/2 J). We performed RNA-sequencing of microglia mRNA from the optic nerve head at a time point following ocular hypertensive insults, but preceding detectable neurodegeneration (with microglia identified as being CD45
Identifiants
pubmed: 32450896
doi: 10.1186/s13041-020-00603-7
pii: 10.1186/s13041-020-00603-7
pmc: PMC7249412
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81Subventions
Organisme : NEI NIH HHS
ID : EY011721
Pays : United States
Organisme : Vetenskapsrådet
ID : 2018-02124
Pays : International
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