Cucurbitacin B Activates Bitter-Sensing Gustatory Receptor Neurons via Gustatory Receptor 33a in
Action Potentials
/ drug effects
Animals
Behavior, Animal
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ drug effects
Feeding Behavior
Insecticides
/ toxicity
Mutation
/ genetics
Receptors, Cell Surface
/ metabolism
Sensory Receptor Cells
/ metabolism
Taste
/ drug effects
Triterpenes
/ chemistry
Cucurbitaceae
Drosophila melanogaster
bitterness
cucurbitacin B
toxicity
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
14
01
2020
revised:
08
04
2020
accepted:
26
04
2020
pubmed:
27
5
2020
medline:
26
1
2021
entrez:
27
5
2020
Statut:
ppublish
Résumé
The Gustatory system enables animals to detect toxic bitter chemicals, which is critical for insects to survive food induced toxicity. Cucurbitacin is widely present in plants such as cucumber and gourds that acts as an anti-herbivore chemical and an insecticide. Cucurbitacin has a harmful effect on insect larvae as well. Although various beneficial effects of cucurbitacin such as alleviating hyperglycemia have also been documented, it is not clear what kinds of molecular sensors are required to detect cucurbitacin in nature. Cucurbitacin B, a major bitter component of bitter melon, was applied to induce action potentials from sensilla of a mouth part of the fly, labellum. Here we identify that only
Identifiants
pubmed: 32451368
pii: molcells.2020.0019
doi: 10.14348/molcells.2020.0019
pmc: PMC7332364
doi:
Substances chimiques
Drosophila Proteins
0
Gr33a protein, Drosophila
0
Insecticides
0
Receptors, Cell Surface
0
Triterpenes
0
cucurbitacin B
0115W5MABF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
530-538Références
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