Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling.

Female Fetus / drug effects HIV Infections / drug therapy HIV Integrase Inhibitors / pharmacokinetics Heterocyclic Compounds, 3-Ring / pharmacokinetics Humans Maternal Exposure Oxazines / pharmacokinetics Piperazines / pharmacokinetics Placenta Pregnancy Pyridones / pharmacokinetics Raltegravir Potassium / pharmacokinetics

Journal

Clinical pharmacokinetics
ISSN: 1179-1926
Titre abrégé: Clin Pharmacokinet
Pays: Switzerland
ID NLM: 7606849

Informations de publication

Date de publication:
11 2020
Historique:
pubmed: 27 5 2020
medline: 22 9 2021
entrez: 27 5 2020
Statut: ppublish

Résumé

Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.

Sections du résumé

BACKGROUND
Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal-fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.

Identifiants

DOI: 10.1007/s40262-020-00897-9 PMID: 32451908 PMC: PMC7666002
pubmed: 32451908
doi: 10.1007/s40262-020-00897-9
pii: 10.1007/s40262-020-00897-9
pmc: PMC7666002
mid: NIHMS1597776
doi:

Substances chimiques

HIV Integrase Inhibitors 0
Heterocyclic Compounds, 3-Ring 0
Oxazines 0
Piperazines 0
Pyridones 0
Raltegravir Potassium 43Y000U234
dolutegravir DKO1W9H7M1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1433-1450

Subventions

Organisme : NICHD NIH HHS
ID : HHSN275201800001C
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068632
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068616
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD087969
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI106716
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275201800001I
Pays : United States

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Auteurs

Xiaomei I Liu (XI)

Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA. rph5862@gmail.com.

Jeremiah D Momper (JD)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.

Natella Y Rakhmanina (NY)

Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.

Dionna J Green (DJ)

Office of Pediatric Therapeutics, US Food and Drug Administration, Silver Spring, MD, USA.

Gilbert J Burckart (GJ)

Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, MD, USA.

Tim R Cressey (TR)

PHPT/IRD 174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Mark Mirochnick (M)

Boston University, School of Medicine, Boston, MA, USA.

Brookie M Best (BM)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.

John N van den Anker (JN)

Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.
Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.

André Dallmann (A)

Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
Clinical Pharmacometrics, Bayer, Leverkusen, Germany.

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Classifications MeSH

questionsmedicales.fr › Structures de l'embryon › Foetus › Prediction of Maternal and Fetal...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Prediction of Maternal and Fetal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Agents antiVIH › Inhibiteurs de l'intégrase du VIH › Prediction of Maternal and Fetal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Prediction of Maternal and Fetal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prediction of Maternal and Fetal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › Prediction of Maternal and Fetal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Prediction of Maternal and Fetal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Prediction of Maternal and Fetal...
questionsmedicales.fr › Structures de l'embryon › Placenta › Prediction of Maternal and Fetal...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prediction of Maternal and Fetal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Prediction of Maternal and Fetal...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Pyrrolidones › Raltégravir de potassium › Prediction of Maternal and Fetal...