Design and rationale of a randomized, placebo-controlled trial on the efficacy and safety of sulodexide for extended treatment in elderly patients after a first venous thromboembolism.
Elderly
Extension
Recurrence
Sulodexide
Venous thromboembolism
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
19
02
2020
accepted:
16
05
2020
pubmed:
27
5
2020
medline:
14
9
2021
entrez:
27
5
2020
Statut:
ppublish
Résumé
How to prevent recurrences after a first venous thromboembolic (VTE) event in elderly patients is still an open issue, especially because of the high bleeding risk of anticoagulation in these patients. The placebo-controlled "Jason" study aims at assessing the efficacy and safety for secondary VTE prevention in elderly patients of oral Sulodexide (Vessel
Identifiants
pubmed: 32451933
doi: 10.1007/s11739-020-02381-5
pii: 10.1007/s11739-020-02381-5
pmc: PMC7952285
doi:
Substances chimiques
Anticoagulants
0
Glycosaminoglycans
0
Placebos
0
glucuronyl glucosamine glycan sulfate
75HGV0062C
Banques de données
ClinicalTrials.gov
['NCT04257487']
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-368Références
J Thromb Haemost. 2017 Oct;15(10):1963-1970
pubmed: 28762665
Circulation. 2011 Aug 16;124(7):824-9
pubmed: 21810658
N Engl J Med. 2010 Dec 23;363(26):2499-510
pubmed: 21128814
Am J Med. 2014 Jun;127(6):530-7.e3
pubmed: 24561112
N Engl J Med. 2013 Feb 21;368(8):699-708
pubmed: 23216615
Arch Intern Med. 1998 Mar 23;158(6):585-93
pubmed: 9521222
Circulation. 2015 Nov 17;132(20):1891-7
pubmed: 26408273
Thromb Haemost. 2000 May;83(5):657-60
pubmed: 10823257
Intern Emerg Med. 2020 Apr;15(3):453-462
pubmed: 31691119
Thromb Haemost. 2008 Nov;100(5):780-8
pubmed: 18989521
J Thromb Haemost. 2015 Nov;13(11):2119-26
pubmed: 26764429
Blood. 2014 Jul 10;124(2):196-203
pubmed: 24879813
Chest. 2016 Feb;149(2):315-352
pubmed: 26867832
CMAJ. 2003 Jan 21;168(2):183-94
pubmed: 12538548
Medicine (Baltimore). 2009 Nov;88(6):366-370
pubmed: 19910751
Am J Med. 2018 Jun;131(6):703.e7-703.e16
pubmed: 29307536
Am J Med. 2017 Feb;130(2):198-206
pubmed: 27742261
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
N Engl J Med. 2003 Sep 25;349(13):1247-56
pubmed: 14507950
N Engl J Med. 2017 Mar 30;376(13):1211-1222
pubmed: 28316279
N Engl J Med. 2013 Aug 29;369(9):799-808
pubmed: 23808982
Thromb Haemost. 2009 Jun;101(6):1112-8
pubmed: 19492156
N Engl J Med. 2012 Apr 5;366(14):1287-97
pubmed: 22449293
Thromb Haemost. 1996 Dec;76(6):1102-7
pubmed: 8972038
J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):977-81
pubmed: 25665832
Circulation. 1993 Oct;88(4 Pt 1):1730-5
pubmed: 8403319
J Thromb Thrombolysis. 2016 Jan;41(1):3-14
pubmed: 26780736
J Thromb Haemost. 2005 Apr;3(4):692-4
pubmed: 15842354
Blood. 2014 Sep 18;124(12):1968-75
pubmed: 24963045