Laser speckle contrast imaging system using nanosecond pulse laser source.
cerebral blood flow
continuous wave
laser speckle contrast imaging
Journal
Journal of biomedical optics
ISSN: 1560-2281
Titre abrégé: J Biomed Opt
Pays: United States
ID NLM: 9605853
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
18
10
2019
accepted:
13
05
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
25
9
2021
Statut:
ppublish
Résumé
Nanosecond-pulsed laser has proven to be used to obtain the velocity of blood using the speckle contrast method. Without the scanning time, it has potential for achieving fast two-dimensional blood flow images in a photoacoustic imaging system with the same pulsed laser. Our study aimed to evaluate the qualities of regional cerebral blood flow (rCBF) obtained in a laser speckle contrast imaging (LSCI) system using continuous wave (cw) and nanosecond pulse laser sources. First, a LSCI system consisting of a cw laser with a wavelength of 632.8 nm and a cw laser/nanosecond pulse laser with a wavelength of 532 nm was developed. This system was used to obtain rCBF images of mouse in vivo with two different laser sources. Continuous wave lasers (532 and 632.8 nm) show different imaging characteristics for rCBF imaging. The rCBF images obtained using 532-nm nanosecond pulse laser showed higher resolution than those using 532-nm cw laser. There was no significant difference in the results using nanosecond pulse laser among various pulse widths or repetition rates. It is proved that a nanosecond pulse laser could be used for LSCI.
Identifiants
pubmed: 32452171
pii: JBO-190370RR
doi: 10.1117/1.JBO.25.5.056005
pmc: PMC7247735
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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