Comparison of biochemical parameters and chemokine levels in pleural fluid between patients with anergic and non-anergic tuberculous pleural effusion.
Adenosine Deaminase
/ analysis
Adult
Aged
Aged, 80 and over
Biomarkers
/ analysis
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
Chemokine CCL27
/ analysis
Female
Flow Cytometry
Humans
Intercellular Signaling Peptides and Proteins
/ analysis
Male
Middle Aged
Pleural Effusion
/ diagnosis
Predictive Value of Tests
Prospective Studies
Protein Array Analysis
Receptors, CCR10
/ analysis
Tuberculosis, Pleural
/ diagnosis
Adenosine deaminase
Anergy
CCL27
CCR10
Tuberculous pleural effusion
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
23
11
2019
revised:
20
02
2020
accepted:
22
04
2020
pubmed:
27
5
2020
medline:
4
9
2021
entrez:
27
5
2020
Statut:
ppublish
Résumé
Pleural fluid (PF) immune response in anergic tuberculous pleural effusion (TPE) patients is poorly understood. This study aimed to compare PF biochemical parameters and chemokine levels between anergic and non-anergic TPE patients. Chemokine arrays, cytokine measurements, and flow cytometry were performed in 58 patients (TPE [non-anergic (n = 32) and anergic (n = 10)] and malignant pleural effusion (MPE) [n = 16]). PF adenosine deaminase 2 (ADA2) levels were significantly lower in anergic TPE patients than in non-anergic TPE patients (p = 0.048). Among the 40 chemokines tested, PF CCL27 levels were significantly higher in anergic TPE patients than in non-anergic TPE and MPE patients (p < 0.001). The percentage of CD4
Identifiants
pubmed: 32452425
pii: S1472-9792(20)30107-4
doi: 10.1016/j.tube.2020.101940
pii:
doi:
Substances chimiques
Biomarkers
0
CCL27 protein, human
0
CCR10 protein, human
0
Chemokine CCL27
0
Intercellular Signaling Peptides and Proteins
0
Receptors, CCR10
0
ADA2 protein, human
EC 3.5.4.4
Adenosine Deaminase
EC 3.5.4.4
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101940Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.