The Balance between the Hemostatic Effect and Immune Response of Hyaluronan Conjugated with Different Chain Lengths of Inorganic Polyphosphate.

Animals Hemostatics Hyaluronic Acid Hydrogels Immunity Mice Polyphosphates

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
13 07 2020
Historique:
pubmed: 27 5 2020
medline: 22 6 2021
entrez: 27 5 2020
Statut: ppublish

Résumé

Inorganic polyphosphate (PolyP) is a potential hemostatic material. However, the effect of PolyP chain length on the immune response and hemostatic function remains to be established. We have developed PolyP-conjugated hyaluronans (HA-PolyPs) with three different short-chain PolyPs (

Identifiants

DOI: 10.1021/acs.biomac.0c00390 PMID: 32453578
pubmed: 32453578
doi: 10.1021/acs.biomac.0c00390
doi:

Substances chimiques

Hemostatics 0
Hydrogels 0
Polyphosphates 0
Hyaluronic Acid 9004-61-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2695-2704

Auteurs

Masashi Okawa (M)

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Megumu Sakoda (M)

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Seiichi Ohta (S)

Center for Disease Biology and Integrative Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
ORCID: 0000-0002-4775-8199

Kiyoshi Hasegawa (K)

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Yutaka Yatomi (Y)

Department of Clinical Laboratory Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Taichi Ito (T)

Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Center for Disease Biology and Integrative Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ORCID: 0000-0002-1589-8242

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Hémostatiques › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Acide hyaluronique › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Balance between the Hemostatic Effect and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Polyphosphates › The Balance between the Hemostatic Effect and...