Delayed-phase thrombocytopenia in patients with coronavirus disease 2019 (COVID-19).
COVID-19
SARS-CoV-2
clinical features
cytokine
lymphocyte
thrombocytopenia
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
07
04
2020
revised:
21
05
2020
accepted:
25
05
2020
pubmed:
27
5
2020
medline:
28
7
2020
entrez:
27
5
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) can affect the haematopoietic system. Thrombocytopenia at admission was prevalent, while late-phase or delayed-phase thrombocytopenia (occurred 14 days after symptom onset) is rare. This retrospective, single-centre study screened 450 COVID-19 patients and enrolled 271 patients at the Union Hospital, Wuhan, China, from January 25 to March 9, 2020. COVID-19-associated delayed-phase thrombocytopenia occurred in 11·8% of enrolling patients. The delayed-phase thrombocytopenia in COVID-19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed-phase thrombocytopenia is significantly associated with increased length of hospital stay and higher mortality rate. Delayed-phase nadir platelet counts demonstrated a significantly negative correlation with B cell percentages. We also provided and described bone marrow aspiration pathology of three patients with delayed-phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that immune-mediated platelet destruction might account for the delayed-phase thrombocytopenia in a group of patients. In addition, clinicians need to pay attention to the delayed-phase thrombocytopenia especially at 3-4 weeks after symptom onset.
Identifiants
pubmed: 32453877
doi: 10.1111/bjh.16885
pmc: PMC7283673
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
179-184Subventions
Organisme : Clinical Innovation Funds of Union Hospital
ID : 2019-125
Pays : International
Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
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