Protein profiling in unlocking the basis of varicocele-associated infertility.
bioinformatics
proteomics
seminal plasma
spermatozoa
varicocele
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
10
01
2020
revised:
21
04
2020
accepted:
24
04
2020
pubmed:
27
5
2020
medline:
22
6
2021
entrez:
27
5
2020
Statut:
ppublish
Résumé
Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Mitochondrial dysfunction has been identified as the main factor affecting normal physiological functions of spermatozoa. This article discusses the proteomic studies of spermatozoa and seminal plasma in varicocele patients. Proteomics can identify potential spermatozoa and seminal plasma biomarkers in varicocele-mediated male infertility. In future, these protein biomarkers can be useful in the development of noninvasive diagnostic and therapeutic strategies for varicocele patients.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13645Informations de copyright
© 2020 Blackwell Verlag GmbH.
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