Some New Hydrazone Derivatives Bearing the 1,2,4-Triazole Moiety as Potential Antimycobacterial Agents.
1
2
4-triazole
Hydrazone
antimycobacterial activity
Journal
Turkish journal of pharmaceutical sciences
ISSN: 2148-6247
Titre abrégé: Turk J Pharm Sci
Pays: Turkey
ID NLM: 101717890
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
26
04
2018
accepted:
04
08
2018
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
27
5
2020
Statut:
ppublish
Résumé
The aim of this study was to synthesize, characterize, and screen some new 1-(4-((2-(4-substitutedphenyl)hydrazono)methyl)phenyl)-1H-1,2,4-triazole derivatives for their antimycobacterial activities. The target compounds The biological assay results showed that the methylsulfonyl-substituted derivative Although the methylsulfonyl-substituted derivative exhibited significant antimycobacterial activity, none of the synthesized compounds was as effective as isoniazid, rifampin, ethambutol, and ciprofloxacin against
Identifiants
pubmed: 32454746
doi: 10.4274/tjps.galenos.2018.43660
pii: 21098
pmc: PMC7227891
doi:
Types de publication
Journal Article
Langues
eng
Pagination
432-436Informations de copyright
©Copyright 2019 Turk J Pharm Sci, Published by Galenos Publishing House.
Déclaration de conflit d'intérêts
Conflict of Interest: No conflict of interest was declared by the authors.
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