GC/MS Analysis of Alkaloids in
Amaryllidaceae alkaloids
Galanthus fosteri
anticholinesterase activity
Journal
Turkish journal of pharmaceutical sciences
ISSN: 2148-6247
Titre abrégé: Turk J Pharm Sci
Pays: Turkey
ID NLM: 101717890
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
09
07
2018
accepted:
11
10
2018
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
27
5
2020
Statut:
ppublish
Résumé
Amaryllidaceae alkaloids are well known for their wide range of pharmacological activities. Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive cholinesterase inhibitor marketed under different commercial names in several countries for the treatment of Alzheimer's disease. The aim of this work was to study the alkaloid profiles of the aerial parts and bulbs of both flowering and fruiting periods of The alkaloid profiles of the four samples were determined by means of gas chromatography-mass spectrometry, and AChE and BuChE inhibition assays were performed by the modified Ellman method. Totally, 22 compounds with mass spectral characteristics of Amaryllidaceae alkaloids were detected in the extracts. Significant AChE and BuChE inhibitory activities were observed in the tested samples (IC This study shows that
Identifiants
pubmed: 32454758
doi: 10.4274/tjps.galenos.2018.26056
pii: 21089
pmc: PMC7227861
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36-42Informations de copyright
©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.
Déclaration de conflit d'intérêts
Conflicts of interest: No conflict of interest was declared by the authors.
Références
Phytother Res. 2011 Nov;25(11):1686-92
pubmed: 21442675
Z Naturforsch C J Biosci. 2009 May-Jun;64(5-6):311-6
pubmed: 19678530
Phytochem Anal. 2005 Mar-Apr;16(2):98-103
pubmed: 15881117
J Pharmacol Exp Ther. 2000 Jun;293(3):896-902
pubmed: 10869390
Fundam Clin Pharmacol. 2012 Jun;26(3):393-401
pubmed: 21480982
Chem Biodivers. 2011 Jan;8(1):115-30
pubmed: 21259423
Life Sci. 2002 Oct 11;71(21):2521-9
pubmed: 12270757
Planta Med. 1988 Dec;54(6):524-6
pubmed: 3212082
Biochem Pharmacol. 1961 Jul;7:88-95
pubmed: 13726518
Bioorg Med Chem Lett. 2010 Sep 1;20(17):5290-4
pubmed: 20655219
J Pharm Biomed Anal. 2015 Jan;102:222-8
pubmed: 25305596
Neuroscience. 2002;110(4):627-39
pubmed: 11934471
Z Naturforsch C J Biosci. 2004 Jan-Feb;59(1-2):65-9
pubmed: 15018055
Phytochem Anal. 2010 Jan-Feb;21(1):80-8
pubmed: 19774542
J Pharm Biomed Anal. 2012 Nov;70:13-25
pubmed: 22673940
Alzheimers Res Ther. 2016 Sep 20;8:39
pubmed: 27646601
J Asian Nat Prod Res. 2017 Jan;19(1):53-100
pubmed: 27406068
Bioorg Med Chem. 2012 Sep 15;20(18):5464-72
pubmed: 22910226
Alkaloids Chem Biol. 2010;68:1-37
pubmed: 20334035
Influenza Other Respir Viruses. 2013 Nov;7(6):922-31
pubmed: 23136954