Development and Functions of the Infant Gut Microflora: Western
Journal
International journal of pediatrics
ISSN: 1687-9740
Titre abrégé: Int J Pediatr
Pays: Egypt
ID NLM: 101517077
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
11
2019
accepted:
07
04
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
27
5
2020
Statut:
epublish
Résumé
The human gut is colonized by trillions of bacteria as well as other microorganisms, collectively referred to as the "gut microflora." This microflora plays an important role in metabolism as well as immunity, and alterations in its normal composition and pattern of colonization can disturb the development and functioning of the immune system, predisposing the individual to several diseases. Neonates acquire their gut microflora from the mother as well as the surroundings, and as the infant grows, the gut microflora undergoes several changes, ultimately acquiring an adult-like composition. Characterization of the gut microflora of healthy infants is important to protect infants from infectious diseases. Furthermore, formulation of prebiotics and probiotics for boosting infant immunity in a specific population also requires prior knowledge of the normal gut microflora in a healthy infant in that population. To this end, several studies have been performed on Western infants; however, the gut microflora of Indian infants is as yet insufficiently studied. Moreover, there has been no comparative analysis of the development and characteristics of the infant gut microflora between the two populations. In this review, we discuss the development and maturation of the infant gut microflora and its effect on immunity, as well as the factors affecting the patterns of colonization. In addition, we compare the patterns of colonization of gut microflora between Western and Indian infants based on the available literature in an attempt to identify the extent of similarity or difference between the two populations.
Identifiants
pubmed: 32454840
doi: 10.1155/2020/7586264
pmc: PMC7229554
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7586264Informations de copyright
Copyright © 2020 Lalit Bharadia et al.
Déclaration de conflit d'intérêts
Authors NA and NJ are employed by Danone India. LB does not have any conflicts of interest to declare.
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