Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
11
2019
revised:
14
02
2020
accepted:
04
03
2020
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
7
1
2021
Statut:
epublish
Résumé
CNS inflammation is a major driver of MS pathology. Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression. Next to these immune-mediated mechanisms, other mediators contribute to MS pathology. These include immune-independent cell death of oligodendrocytes and neurons as well as oxidative stress-induced tissue damage. In particular, the complex influence of oxidative stress on inflammation and vice versa makes therapeutic interference complex. All approved MS therapeutics work by modulating the autoimmune response. However, despite substantial developments in the treatment of the relapsing-remitting form of MS, approved therapies for the progressive forms of MS as well as for MS-associated concomitants are limited and much needed. Here, we summarize the contribution of inflammation and oxidative stress to MS pathology and discuss consequences for MS therapy development.
Identifiants
pubmed: 32454942
doi: 10.1155/2020/7191080
pmc: PMC7240663
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7191080Informations de copyright
Copyright © 2020 Valentina Pegoretti et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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