Type 2 Autoimmune Polyglandular Syndrome Presenting with Hyperpigmentation and Amenorrhea.
adrenal insufficiency
amenorrhea
aps
autoimmune polyglandular syndrome
schmidt syndrome
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
21 Apr 2020
21 Apr 2020
Historique:
entrez:
27
5
2020
pubmed:
27
5
2020
medline:
27
5
2020
Statut:
epublish
Résumé
A 36-year-old female presented with lethargy, anorexia, nausea, hyperpigmentation, weight loss and amenorrhea for six months. On examination, she had hyperpigmentation of face, hands and oral mucosa. Investigations revealed adrenal insufficiency and subclinical hyperthyroidism with elevated anti-thyroid peroxidase antibodies. Adrenal insufficiency in combination with Grave's disease and/or type 1 diabetes mellitus occurs in type 2 autoimmune polyglandular syndrome. It is a polygenic disorder occurring due to mutations in the human leukocyte antigen complex on chromosome 6. The patient was treated with oral hydrocortisone which led to improvement in all the symptoms.
Identifiants
pubmed: 32455083
doi: 10.7759/cureus.7772
pmc: PMC7243617
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e7772Informations de copyright
Copyright © 2020, Gaba et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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