Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles.
NSAID
age
alcohol
blood collection
confounding
metabolites
metabolomics
physical activity
processing
sample handling
sex
smoking
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
21 May 2020
21 May 2020
Historique:
received:
16
04
2020
revised:
14
05
2020
accepted:
19
05
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Demographic, lifestyle and biospecimen-related factors at the time of blood collection can influence metabolite levels in epidemiological studies. Identifying the major influences on metabolite concentrations is critical to designing appropriate sample collection protocols and considering covariate adjustment in metabolomics analyses. We examined the association of age, sex, and other short-term pre-blood collection factors (time of day, season, fasting duration, physical activity, NSAID use, smoking and alcohol consumption in the days prior to collection) with 133 targeted plasma metabolites (acylcarnitines, amino acids, biogenic amines, sphingolipids, glycerophospholipids, and hexoses) among 108 individuals that reported exposures within 48 h before collection. The differences in mean metabolite concentrations were assessed between groups based on pre-collection factors using two-sided
Identifiants
pubmed: 32455751
pii: metabo10050213
doi: 10.3390/metabo10050213
pmc: PMC7281389
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Institut National Du Cancer
ID : 2014-007
Organisme : NCI NIH HHS
ID : U01 CA206110
Pays : United States
Organisme : Bundesministerium für Bildung und Forschung
ID : 01KT1512
Organisme : NCI NIH HHS
ID : R01 CA189184, R01 CA207371, and U01 CA206110
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207371
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA222060
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. C.M.U. has as cancer center director oversight over research funded by several pharmaceutical companies, but has not received funding directly herself.
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