Relapse-Free Survival and PD-L1 Expression in First High- and Low-Grade Relapsed Luminal, Basal and Double-Negative P53-Mutant Non-Muscular Invasive Bladder Cancer Depending on Previous Chemo- and Immunotherapy.

PD-L1 expression immune cells malignant cells molecular subtype non-muscular invasive bladder cancer relapse survival tumor grade

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
21 May 2020
Historique:
received: 29 04 2020
revised: 15 05 2020
accepted: 19 05 2020
entrez: 28 5 2020
pubmed: 28 5 2020
medline: 28 5 2020
Statut: epublish

Résumé

The goal of this study was to assess how PD-L1 expression in tissue specimens of patients with main molecular subtypes of NMIBC (luminal, basal and double-negative p53-mutant) associates with relapsed-free survival in dependence on the tumor grade and prior treatment of primary bladder cancer. PD-L1 expressions on the membrane of neoplastic and CD8+ immune cells were assessed in tumor specimens (

Identifiants

pubmed: 32455829
pii: cancers12051316
doi: 10.3390/cancers12051316
pmc: PMC7281187
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Russian academic excellence project "5-100" for Sechenov First Moscow State Medical University
ID : 5-100

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Auteurs

Ekaterina Blinova (E)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Dmitry Enikeev (D)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Dmitry Roshchin (D)

Department of Oncological Urology, Russian National Research Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.

Elena Samyshina (E)

Laboratory of Molecular Pharmacology and Drug Design, All-Union Research Center for Biological Active Compounds Safety, 23 Kirova Street, 142450 Staraja Kupavna, Russia.

Olga Deryabina (O)

Department of Oncology, Laboratory of Pharmacology, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Street, 430005 Saransk, Russia.

Aleksander Tertychnyy (A)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Dmitry Blinov (D)

Laboratory of Molecular Pharmacology and Drug Design, All-Union Research Center for Biological Active Compounds Safety, 23 Kirova Street, 142450 Staraja Kupavna, Russia.

Evgenia Kogan (E)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Marina Dudina (M)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Haydar Barakat (H)

Department of Bioinformatics, People's Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.

Dmitrij Merinov (D)

Department of Oncological Urology, Russian National Research Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.

Aleksandr Kachmazov (A)

Department of Oncological Urology, Russian National Research Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.

Stanislav Serebrianyi (S)

Department of Oncological Urology, Russian National Research Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.

Natalia Potoldykova (N)

Department of Clinical Anatomy and Operative Surgery, Department of Pathological Anatomy, Institute for Urology and Reproductive Health, Sechenov University, 8/1 Trubetzkaya Street, 119991 Moscow, Russia.

Dmitrij Perepechin (D)

Department of Oncological Urology, Russian National Research Center of Radiology, 3 2nd Botkinsky Proezd, 125284 Moscow, Russia.

Classifications MeSH