Sonic Hedgehog and Triiodothyronine Pathway Interact in Mouse Embryonic Neural Stem Cells.
cell differentiation
embryonic neural stem cells
sonic hedgehog
triiodothyronine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 May 2020
23 May 2020
Historique:
received:
09
04
2020
revised:
13
05
2020
accepted:
19
05
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Neural stem cells are fundamental to development of the central nervous system (CNS)-as well as its plasticity and regeneration-and represent a potential tool for neuro transplantation therapy and research. This study is focused on examination of the proliferation dynamic and fate of embryonic neural stem cells (eNSCs) under differentiating conditions. In this work, we analyzed eNSCs differentiating alone and in the presence of sonic hedgehog (SHH) or triiodothyronine (T3) which play an important role in the development of the CNS. We found that inhibition of the SHH pathway and activation of the T3 pathway increased cellular health and survival of differentiating eNSCs. In addition, T3 was able to increase the expression of the gene for the receptor smoothened (
Identifiants
pubmed: 32456161
pii: ijms21103672
doi: 10.3390/ijms21103672
pmc: PMC7279276
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Shh protein, mouse
0
Smo protein, mouse
0
Smoothened Receptor
0
Thyroid Hormone Receptors beta
0
Triiodothyronine
06LU7C9H1V
iodothyronine deiodinase type III
EC 1.11.1.-
Iodide Peroxidase
EC 1.11.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education Youth and Sports of the Czech Republic
ID : National Sustainability Program I (NPU I) Nr. LO1503
Organisme : Charles University Research Fund
ID : project number Q39
Organisme : Ministry of Education, Youth and Sports of the Czech Republic
ID : No. CZ.02.1.01/0.0/0.0/16_019/0000787 "Fighting INfectious Diseases"
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