γδ T Cells: The Ideal Tool for Cancer Immunotherapy.
adoptive cell therapy
allogeneic
bisphosphonate
expansion
gamma delta T cell
immunotherapy
phosphoantigen
third-party
transduction
γδ T cell
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 05 2020
24 05 2020
Historique:
received:
19
04
2020
revised:
20
05
2020
accepted:
21
05
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
25
2
2021
Statut:
epublish
Résumé
γδ T cells have recently gained considerable attention as an attractive tool for cancer adoptive immunotherapy due to their potent anti-tumor activity and unique role in immunosurveillance. The remarkable success of engineered T cells for the treatment of hematological malignancies has revolutionized the field of adoptive cell immunotherapy. Accordingly, major efforts are underway to translate this exciting technology to the treatment of solid tumors and the development of allogeneic therapies. The unique features of γδ T cells, including their major histocompatibility complex (MHC)-independent anti-cancer activity, tissue tropism, and multivalent response against a broad spectrum of the tumors, render them ideal for designing universal 'third-party' cell products, with the potential to overcome the challenges of allogeneic cell therapy. In this review, we describe the crucial role of γδ T cells in anti-tumor immunosurveillance and we summarize the different approaches used for the ex vivo and in vivo expansion of γδ T cells suitable for the development of novel strategies for cancer therapy. We further discuss the different transduction strategies aiming at redirecting or improving the function of γδ T cells, as well as, the considerations for the clinical applications.
Identifiants
pubmed: 32456316
pii: cells9051305
doi: 10.3390/cells9051305
pmc: PMC7290982
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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