Goatpox virus (G20-LKV) vaccine strain elicits a protective response in cattle against lumpy skin disease at challenge with lumpy skin disease virulent field strain in a comparative study.
Cattle
G20-LKV vaccine strain
Goatpox (GTP)
Lumpy skin disease (LSD)
Niskhi vaccine strain
Poxviruses
Sheeppox (SPP)
Vaccine
Journal
Veterinary microbiology
ISSN: 1873-2542
Titre abrégé: Vet Microbiol
Pays: Netherlands
ID NLM: 7705469
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
10
01
2020
revised:
12
04
2020
accepted:
15
04
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
2
2
2021
Statut:
ppublish
Résumé
In this comparative study, we examine the safety of the sheeppox (SPP) and goatpox (GTP) vaccines and the protective response of these vaccines in cattle against a virulent lumpy skin disease (LSD) field strain. The vaccine safety was tested in rabbits, mice and cattle using ten times recommended dose. In the safety trial, none of the vaccinated animals showed any deviation from physiological norms or fever, inappetence or local/ generalized skin reactions. In the challenge trial, both SPP and GTP vaccine groups developed virus-neutralizing antibodies with an average titre of 2.1 log
Identifiants
pubmed: 32456811
pii: S0378-1135(20)30041-9
doi: 10.1016/j.vetmic.2020.108695
pii:
doi:
Substances chimiques
Viral Vaccines
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108695Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.