Decreased, Deformed, Defective-How HIV-1 Vpu Targets Peroxisomes.
Vpu
human immunodeficiency virus
miRNA
peroxisomes
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
26 05 2020
26 05 2020
Historique:
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
22
7
2020
Statut:
epublish
Résumé
Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral pathogens modulate biogenesis or function of peroxisomes to evade innate sensing and restriction. In a recent study, Hobman and colleagues found that the accessory viral protein u (Vpu) of HIV-1 inhibits peroxisome activity by depleting cellular peroxisome pools. This depletion could be ascribed to a Vpu-dependent induction of four microRNAs (miRNAs) that suppress the expression of peroxisomal biogenesis factors PEX2, PEX7, PEX11B, and PEX13. Although the downstream effects on antiretroviral gene expression and HIV-1 replication remain to be determined, these findings provide important insights into peroxisome biogenesis and the modulation of cell organelles by HIV-1 Vpu.
Identifiants
pubmed: 32457250
pii: mBio.00967-20
doi: 10.1128/mBio.00967-20
pmc: PMC7251213
pii:
doi:
Substances chimiques
Human Immunodeficiency Virus Proteins
0
Viral Regulatory and Accessory Proteins
0
vpu protein, Human immunodeficiency virus 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2020 Hopfensperger and Sauter.
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