Niche rather than origin dysregulates mucosal Langerhans cells development in aged mice.
Age Factors
Aging
/ physiology
Animals
Biomarkers
Bone Morphogenetic Protein 7
/ genetics
Cell Differentiation
/ genetics
Cellular Microenvironment
/ genetics
Cellular Senescence
/ genetics
Epidermal Cells
/ immunology
Epidermis
/ immunology
Gene Expression
Gingiva
/ immunology
Immunophenotyping
Langerhans Cells
/ cytology
Mice
Microbiota
Mucous Membrane
/ immunology
Transforming Growth Factor beta1
/ genetics
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
05
01
2020
accepted:
19
04
2020
revised:
02
04
2020
pubmed:
28
5
2020
medline:
8
7
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
Unlike epidermal Langerhans cells (LCs) that originate from embryonic precursors and are self-renewed locally, mucosal LCs arise and are replaced by circulating bone marrow (BM) precursors throughout life. While the unique lifecycle of epidermal LCs is associated with an age-dependent decrease in their numbers, whether and how aging has an impact on mucosal LCs remains unclear. Focusing on gingival LCs we found that mucosal LCs are reduced with age but exhibit altered morphology with that observed in aged epidermal LCs. The reduction of gingival but not epidermal LCs in aged mice was microbiota-dependent; nevertheless, the impact of the microbiota on gingival LCs was indirect. We next compared the ability of young and aged BM precursors to differentiate to mucosal LCs. Mixed BM chimeras, as well as differentiation cultures, demonstrated that aged BM has intact if not superior capacity to differentiate into LCs than young BM. This was in line with the higher percentages of mucosal LC precursors, pre-DCs, and monocytes, detected in aged BM. These findings suggest that while aging is associated with reduced LC numbers, the niche rather than the origin controls this process in mucosal barriers.
Identifiants
pubmed: 32457449
doi: 10.1038/s41385-020-0301-y
pii: S1933-0219(22)00342-7
doi:
Substances chimiques
Biomarkers
0
Bone Morphogenetic Protein 7
0
Tgfb1 protein, mouse
0
Transforming Growth Factor beta1
0
bmp7 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
767-776Références
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