Mechanisms, regulation and functions of the unfolded protein response.
Journal
Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
accepted:
14
04
2020
pubmed:
28
5
2020
medline:
11
11
2020
entrez:
28
5
2020
Statut:
ppublish
Résumé
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases, including cancer, diabetes, obesity and neurodegeneration. ER proteostasis surveillance is mediated by the unfolded protein response (UPR), a signal transduction pathway that senses the fidelity of protein folding in the ER lumen. The UPR transmits information about protein folding status to the nucleus and cytosol to adjust the protein folding capacity of the cell or, in the event of chronic damage, induce apoptotic cell death. Recent advances in the understanding of the regulation of UPR signalling and its implications in the pathophysiology of disease might open new therapeutic avenues.
Identifiants
pubmed: 32457508
doi: 10.1038/s41580-020-0250-z
pii: 10.1038/s41580-020-0250-z
pmc: PMC8867924
mid: NIHMS1773650
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-438Subventions
Organisme : NIDDK NIH HHS
ID : R24 DK110973
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103185
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113171
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR066634
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA198103
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK090313
Pays : United States
Références
Science. 1990 Mar 30;247(4950):1581-4
pubmed: 2321018
Mol Cell Biol. 1998 Dec;18(12):7499-509
pubmed: 9819435
Cell. 2007 Jun 29;129(7):1337-49
pubmed: 17604722
Science. 2004 Oct 15;306(5695):457-61
pubmed: 15486293
J Clin Invest. 2010 Mar;120(3):744-55
pubmed: 20160352
Nature. 2009 Feb 5;457(7230):687-93
pubmed: 19079236
Mol Cell. 2018 Jan 18;69(2):238-252.e7
pubmed: 29351844
Sci Signal. 2014 Jun 10;7(329):ra54
pubmed: 24917591
Cell. 2019 Nov 27;179(6):1306-1318.e18
pubmed: 31761535
Elife. 2019 Dec 24;8:
pubmed: 31873072
J Cell Biol. 2009 Aug 10;186(3):323-31
pubmed: 19651891
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5886-E5895
pubmed: 27651490
Nat Rev Neurol. 2017 Aug;13(8):477-491
pubmed: 28731040
Cell. 2009 Aug 7;138(3):562-75
pubmed: 19665977
Cell Metab. 2009 Jul;10(1):13-26
pubmed: 19583950
Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):423-8
pubmed: 21543844
Brain Res. 2016 Oct 1;1648(Pt B):530-537
pubmed: 27021956
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4628-33
pubmed: 23487760
Nat Commun. 2019 Jan 24;10(1):323
pubmed: 30679434
Science. 2006 Jul 7;313(5783):104-7
pubmed: 16825573
Cell Rep. 2016 Feb 16;14(6):1382-1394
pubmed: 26854229
ACS Med Chem Lett. 2013 Aug 12;4(10):964-8
pubmed: 24900593
Diabetes. 2014 Jan;63(1):152-61
pubmed: 23990363
Cell. 1986 Jul 18;46(2):291-300
pubmed: 3087629
Trends Endocrinol Metab. 2017 Jan;28(1):32-45
pubmed: 27670636
Nat Immunol. 2017 May;18(5):519-529
pubmed: 28346409
Nat Immunol. 2003 Apr;4(4):321-9
pubmed: 12612580
Science. 2001 Apr 27;292(5517):727-30
pubmed: 11326099
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):757-62
pubmed: 18178615
Neurol Res. 2018 Mar;40(3):189-196
pubmed: 29334839
Cell. 1993 Jun 18;73(6):1197-206
pubmed: 8513503
FASEB J. 2019 Jul;33(7):7896-7914
pubmed: 30912978
PLoS One. 2012;7(12):e51290
pubmed: 23236464
Cell. 2019 Jan 24;176(3):581-596.e18
pubmed: 30661753
Nature. 2011 May 26;473(7348):528-31
pubmed: 21532591
Diabetes. 2016 Nov;65(11):3369-3383
pubmed: 27507854
Genes Dev. 2009 Oct 1;23(19):2294-306
pubmed: 19762508
Mol Cell. 2009 Mar 27;33(6):679-91
pubmed: 19328063
Antioxid Redox Signal. 2007 Dec;9(12):2305-21
pubmed: 17887918
Hepatology. 2017 Mar;65(3):983-998
pubmed: 28039913
Genes Cells. 2013 Apr;18(4):288-301
pubmed: 23387983
Trends Cancer. 2016 May;2(5):252-262
pubmed: 28741511
Cell. 2006 Feb 10;124(3):587-99
pubmed: 16469704
Mol Cell. 2014 Feb 20;53(4):562-576
pubmed: 24508390
Nat Cell Biol. 2019 Jun;21(6):755-767
pubmed: 31110288
PLoS Biol. 2010 Jul 06;8(7):e1000415
pubmed: 20625545
Cell Metab. 2012 Aug 8;16(2):250-64
pubmed: 22883233
EMBO J. 2012 May 16;31(10):2322-35
pubmed: 22510886
Science. 2007 Nov 9;318(5852):944-9
pubmed: 17991856
Mol Cell. 2000 Dec;6(6):1355-64
pubmed: 11163209
Nat Cell Biol. 2013 May;15(5):481-90
pubmed: 23624402
Cell. 2017 Dec 14;171(7):1625-1637.e13
pubmed: 29198525
J Cell Biol. 2007 Oct 8;179(1):75-86
pubmed: 17923530
Nat Genet. 2015 Jul;47(7):757-65
pubmed: 26029869
Sci Rep. 2016 Feb 24;6:21709
pubmed: 26906090
FEBS J. 2019 Jan;286(2):342-355
pubmed: 29476642
Nat Med. 2011 Jun 12;17(7):812-5
pubmed: 21666694
Nature. 1988 Mar 31;332(6163):462-4
pubmed: 3352747
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29311133
Science. 2012 Nov 9;338(6108):818-22
pubmed: 23042294
Cell Death Dis. 2019 Jun 21;10(7):490
pubmed: 31227689
Curr Biol. 2019 Jul 22;29(14):2322-2338.e7
pubmed: 31303493
Science. 2011 Sep 30;333(6051):1891-4
pubmed: 21852455
Exp Cell Res. 2009 Sep 10;315(15):2496-504
pubmed: 19538957
Endocrinology. 2014 Mar;155(3):769-82
pubmed: 24424044
Nat Immunol. 2010 May;11(5):411-8
pubmed: 20351694
Nature. 2012 May 06;485(7399):507-11
pubmed: 22622579
EMBO J. 2019 Aug 1;38(15):e100999
pubmed: 31368599
Elife. 2020 Jan 06;9:
pubmed: 31904339
Nat Cell Biol. 2018 Aug;20(8):942-953
pubmed: 30013108
Mol Cell. 2016 Aug 18;63(4):553-566
pubmed: 27540856
Sci Signal. 2018 May 15;11(530):
pubmed: 29764990
Cell Metab. 2010 Apr 7;11(4):331-9
pubmed: 20374965
Diabetes. 2017 Jan;66(1):177-192
pubmed: 27634225
Cancer Res. 2007 Apr 15;67(8):3496-9
pubmed: 17440054
Aging Cell. 2017 Aug;16(4):615-623
pubmed: 28436203
Mol Cell. 2017 Jun 15;66(6):761-771
pubmed: 28622521
Immunity. 2004 Jul;21(1):81-93
pubmed: 15345222
J Cell Biol. 2004 Oct 11;167(1):27-33
pubmed: 15479734
J Exp Med. 2007 Oct 1;204(10):2267-75
pubmed: 17875675
EMBO J. 2011 Sep 16;30(21):4465-78
pubmed: 21926971
Mol Cell. 2003 Mar;11(3):619-33
pubmed: 12667446
Cell. 1996 Nov 1;87(3):391-404
pubmed: 8898193
Mol Biol Cell. 2010 Sep 1;21(17):2975-86
pubmed: 20631254
Immunity. 2015 Sep 15;43(3):451-62
pubmed: 26341399
J Clin Invest. 2002 Nov;110(10):1389-98
pubmed: 12438434
Dev Cell. 2007 Sep;13(3):351-64
pubmed: 17765679
J Biol Chem. 2002 May 24;277(21):18346-56
pubmed: 11897784
Mol Ther. 2018 Jun 6;26(6):1404-1413
pubmed: 29728295
Mol Biol Cell. 2018 Jun 1;29(11):1376-1388
pubmed: 29851562
J Biol Chem. 1989 Dec 5;264(34):20602-7
pubmed: 2511206
Cell. 2008 Jan 11;132(1):89-100
pubmed: 18191223
Elife. 2013 May 28;2:e00498
pubmed: 23741617
Nat Med. 2005 Jul;11(7):757-64
pubmed: 15980866
J Cell Biol. 2003 Nov 24;163(4):767-75
pubmed: 14638860
Cell Rep. 2016 Oct 25;17(5):1207-1216
pubmed: 27783936
Sci Adv. 2017 Oct 18;3(10):e1701383
pubmed: 29057323
Cell Death Differ. 2018 Aug;25(8):1530-1531
pubmed: 29991746
Mol Cell. 2004 Aug 13;15(3):355-66
pubmed: 15304216
EMBO Rep. 2008 May;9(5):480-5
pubmed: 18369366
Science. 2006 Apr 28;312(5773):572-6
pubmed: 16645094
Mol Cell. 2017 Aug 17;67(4):673-684.e8
pubmed: 28689662
Cell Metab. 2012 Aug 8;16(2):265-73
pubmed: 22883234
Cell Death Dis. 2012 Feb 16;3:e272
pubmed: 22337234
Sci Signal. 2010 Jan 26;3(106):ra7
pubmed: 20103773
J Cell Biol. 2004 Oct 11;167(1):35-41
pubmed: 15466483
EMBO J. 1998 Oct 1;17(19):5708-17
pubmed: 9755171
Dev Cell. 2012 Dec 11;23(6):1141-52
pubmed: 23237951
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15852-7
pubmed: 21911379
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74
pubmed: 15277680
J Clin Invest. 2008 Oct;118(10):3378-89
pubmed: 18776938
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2809-14
pubmed: 16478805
Mol Cell Biol. 2014 May;34(10):1839-49
pubmed: 24636989
Nat Chem Biol. 2019 Aug;15(8):764-775
pubmed: 31320759
Science. 2008 Feb 15;319(5865):916-9
pubmed: 18276881
Cell. 2001 Dec 28;107(7):881-91
pubmed: 11779464
J Biol Chem. 2018 Mar 16;293(11):4110-4121
pubmed: 29386355
Mol Cell. 2014 May 22;54(4):559-72
pubmed: 24746698
Science. 2005 Mar 25;307(5717):1965-9
pubmed: 15790857
Cell. 1992 Feb 7;68(3):585-96
pubmed: 1739968
Nat Cell Biol. 2017 Jun;19(6):698-710
pubmed: 28459443
Hum Mol Genet. 2012 May 15;21(10):2245-62
pubmed: 22337954
EMBO J. 2005 Dec 21;24(24):4368-80
pubmed: 16362047
Dev Cell. 2018 Aug 6;46(3):327-343.e7
pubmed: 30086303
Dev Cell. 2008 Dec;15(6):829-40
pubmed: 19081072
Cell. 2003 May 16;113(4):519-31
pubmed: 12757712
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2694-9
pubmed: 26427795
Sci Adv. 2020 Jan 01;6(1):eaaz1441
pubmed: 31911951
Cell Rep. 2013 Apr 25;3(4):1279-92
pubmed: 23583182
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14343-8
pubmed: 16973740
Cell Death Differ. 2012 Jun;19(6):1013-26
pubmed: 22240901
Elife. 2018 Jan 05;7:
pubmed: 29303481
Science. 2015 Jul 31;349(6247):500-6
pubmed: 26228140
J Exp Med. 2017 Feb;214(2):401-422
pubmed: 28082357
EMBO J. 2013 Aug 28;32(17):2348-61
pubmed: 23921556
EMBO J. 2019 Aug 1;38(15):e100990
pubmed: 31368601
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84
pubmed: 16365312
Nat Cell Biol. 2000 Jun;2(6):326-32
pubmed: 10854322
Cold Spring Harb Perspect Biol. 2020 Apr 1;12(4):
pubmed: 30962274
Dev Cell. 2015 Dec 7;35(5):553-567
pubmed: 26651292
Biochem Biophys Res Commun. 2008 Nov 28;376(4):758-63
pubmed: 18809377
Cell. 1993 Aug 27;74(4):743-56
pubmed: 8358794
Nat Struct Mol Biol. 2019 Nov;26(11):1053-1062
pubmed: 31695187
Dev Cell. 2015 Mar 23;32(6):678-92
pubmed: 25752962
Nat Genet. 2000 Aug;25(4):406-9
pubmed: 10932183
EMBO J. 2011 Apr 6;30(7):1357-75
pubmed: 21407177
J Clin Invest. 2014 Jun;124(6):2585-98
pubmed: 24812669
Nature. 1983 Nov 24-30;306(5941):387-9
pubmed: 6417546
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9946-51
pubmed: 12902539
J Exp Med. 2009 Sep 28;206(10):2151-9
pubmed: 19752183
Cell Metab. 2018 Apr 3;27(4):828-842.e7
pubmed: 29551590
Nat Cell Biol. 2009 Dec;11(12):1473-80
pubmed: 19855386
Trends Neurosci. 2018 Sep;41(9):610-624
pubmed: 29945734
Sci Rep. 2015 Oct 08;5:14812
pubmed: 26446798
Annu Rev Med. 2006;57:33-47
pubmed: 16409135
Mol Cell Biol. 1989 Oct;9(10):4196-203
pubmed: 2573827
Genes Dev. 2004 Dec 15;18(24):3066-77
pubmed: 15601821
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6804-9
pubmed: 24753614
Mol Cell Biol. 2004 Dec;24(23):10161-8
pubmed: 15542827
Cold Spring Harb Perspect Biol. 2019 Sep 3;11(9):
pubmed: 30670466
Mol Cell. 2013 Mar 28;49(6):1049-59
pubmed: 23395000
Mol Biol Cell. 2011 Sep;22(18):3520-32
pubmed: 21775630
Science. 2011 Nov 25;334(6059):1081-6
pubmed: 22116877
Science. 2019 Jul 19;365(6450):
pubmed: 31320508
Mol Cell. 2018 Aug 16;71(4):629-636.e5
pubmed: 30118681
J Biol Chem. 2014 Oct 31;289(44):30567-30577
pubmed: 25225294
J Exp Med. 2013 Sep 23;210(10):2041-56
pubmed: 24043762
J Biol Chem. 2007 Nov 23;282(47):34525-34
pubmed: 17890727
Cell Metab. 2014 Sep 2;20(3):471-82
pubmed: 25017942
Nat Commun. 2019 Mar 6;10(1):1084
pubmed: 30842412
Hepatology. 2018 Aug;68(2):533-546
pubmed: 29506314
Nat Cell Biol. 2012 Jan 08;14(2):192-200
pubmed: 22231169
PLoS Biol. 2006 Nov;4(11):e374
pubmed: 17090218
Annu Rev Immunol. 2015;33:107-38
pubmed: 25493331
J Biol Chem. 2008 Jun 27;283(26):17954-61
pubmed: 18375386
Nat Rev Mol Cell Biol. 2016 Feb;17(2):69-82
pubmed: 26627931
Mol Cell Biol. 2001 Feb;21(4):1249-59
pubmed: 11158311
Nat Commun. 2014 Apr 07;5:3554
pubmed: 24704861
Nat Commun. 2017 May 26;8(1):18
pubmed: 28550308
Elife. 2019 Jun 27;8:
pubmed: 31246176
Cell Death Differ. 2017 Sep;24(9):1478-1487
pubmed: 28622296
J Cell Biol. 2004 Nov 8;167(3):445-56
pubmed: 15520230
Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2490-6
pubmed: 16931790
Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1533-1542
pubmed: 31871156
J Clin Invest. 2005 Feb;115(2):268-81
pubmed: 15690081
Mol Biol Cell. 1999 Nov;10(11):3787-99
pubmed: 10564271
J Biol Chem. 2004 Aug 13;279(33):34898-902
pubmed: 15184376
Nature. 1999 Jan 21;397(6716):271-4
pubmed: 9930704
J Cell Biol. 2001 May 28;153(5):1011-22
pubmed: 11381086
Mol Cell. 2017 Mar 2;65(5):885-899.e6
pubmed: 28238652
Cell Rep. 2015 Feb 10;10(5):684-693
pubmed: 25660019
Elife. 2015 May 20;4:
pubmed: 25993558
Nature. 2014 Apr 3;508(7494):103-107
pubmed: 24670641
Mol Cell Biol. 2007 Feb;27(3):1027-43
pubmed: 17101776
Brain. 2017 Jun 1;140(6):1768-1783
pubmed: 28430857
J Biol Chem. 1998 Dec 11;273(50):33741-9
pubmed: 9837962
Mol Cell Biol. 2017 Jun 29;37(14):
pubmed: 28461393
Immunity. 2003 Feb;18(2):243-53
pubmed: 12594951
Sci Transl Med. 2018 May 2;10(439):
pubmed: 29720449
Mol Cell. 2009 Apr 24;34(2):191-200
pubmed: 19394296
J Cell Biol. 1980 Oct;87(1):180-96
pubmed: 7191426
Oncogene. 2015 Jan 15;34(3):269-80
pubmed: 24561528
Cell Death Differ. 2018 Jan;25(1):226
pubmed: 28984868
Neuron. 1998 Dec;21(6):1315-25
pubmed: 9883725
Nat Rev Mol Cell Biol. 2013 May;14(5):283-96
pubmed: 23609508
Elife. 2015 Feb 18;4:
pubmed: 25692299
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan;1865(1):158449
pubmed: 31028913
Cell Metab. 2017 Apr 4;25(4):883-897.e8
pubmed: 28380378
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3840-4
pubmed: 198809
PLoS Biol. 2015 Oct 15;13(10):e1002277
pubmed: 26469762
Acta Neuropathol. 2017 Sep;134(3):489-506
pubmed: 28341998
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
pubmed: 17565364
Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193
pubmed: 30655609
Mol Metab. 2013 Aug 03;2(4):405-16
pubmed: 24327956
Cell. 2013 Jun 20;153(7):1435-47
pubmed: 23791175
J Neurochem. 2018 Jan;144(1):35-49
pubmed: 28921568
EMBO J. 2005 Oct 5;24(19):3470-81
pubmed: 16148948
Cell Struct Funct. 2013 Jul 6;38(2):135-43
pubmed: 23666407
Nature. 2002 Jan 3;415(6867):92-6
pubmed: 11780124
Physiol Rev. 2007 Oct;87(4):1377-408
pubmed: 17928587
Cell. 2001 Dec 28;107(7):893-903
pubmed: 11779465
Hepatology. 2012 Apr;55(4):1070-82
pubmed: 22095841
PLoS One. 2014 Nov 13;9(11):e112761
pubmed: 25393282
Elife. 2019 Aug 27;8:
pubmed: 31453810
EMBO J. 2013 Sep 11;32(18):2477-90
pubmed: 23942232
Cell Metab. 2006 Sep;4(3):245-54
pubmed: 16950141
Science. 2018 Aug 3;361(6401):
pubmed: 30072511
Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17383-17392
pubmed: 31413197
Science. 2011 Feb 4;331(6017):586-9
pubmed: 21233347
Mol Cell. 2009 Sep 11;35(5):551-61
pubmed: 19748352
Cell Cycle. 2018;17(15):1901-1916
pubmed: 30109813
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7
pubmed: 19181853
Cell Death Differ. 2012 Nov;19(11):1880-91
pubmed: 22705852
Mol Cell. 2018 Jan 18;69(2):169-181
pubmed: 29107536
Genes Dev. 1998 Jun 15;12(12):1812-24
pubmed: 9637683
Nat Commun. 2020 May 14;11(1):2401
pubmed: 32409639
Mol Cell. 2001 Jun;7(6):1153-63
pubmed: 11430819
Nat Immunol. 2019 Jul;20(7):865-878
pubmed: 31086333
Elife. 2018 Dec 24;7:
pubmed: 30582518
Elife. 2017 Oct 03;6:
pubmed: 28971800
Mol Biol Cell. 2017 Aug 15;28(17):2318-2332
pubmed: 28615323
Science. 2014 Jul 4;345(6192):98-101
pubmed: 24994655
J Cell Sci. 2009 May 15;122(Pt 10):1626-36
pubmed: 19420237