Cortical Inhibitory Imbalance in Functional Paralysis.
functional neurological disorders
functional paralysis
motor threshold
short interval intracortical inhibition
transcranial magnetic stimulation
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
02
2020
accepted:
06
04
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Functional neurological disorders are characterized by neurological symptoms that have no identifiable pathology and little is known about their underlying pathophysiology. To analyze motor cortex excitability and intracortical inhibitory and excitatory circuits' imbalance in patients with flaccid functional weakness. Twenty-one consecutive patients with acute onset of flaccid functional weakness were recruited. Single and paired-pulse transcranial magnetic stimulation (TMS) protocols were used to analyze resting motor thresholds (RMT) and intracortical inhibitory (short interval intracortical inhibition - SICI) and excitatory (intracortical facilitation - ICF) circuits' imbalance between the affected and non-affected motor cortices. We observed a significant increase in RMT and SICI in the affected motor cortex ( This study extends current knowledge of functional weakness, arguing for a specific central nervous system abnormality which may be involved in the symptoms' pathophysiology.
Sections du résumé
BACKGROUND
BACKGROUND
Functional neurological disorders are characterized by neurological symptoms that have no identifiable pathology and little is known about their underlying pathophysiology.
OBJECTIVES
OBJECTIVE
To analyze motor cortex excitability and intracortical inhibitory and excitatory circuits' imbalance in patients with flaccid functional weakness.
METHODS
METHODS
Twenty-one consecutive patients with acute onset of flaccid functional weakness were recruited. Single and paired-pulse transcranial magnetic stimulation (TMS) protocols were used to analyze resting motor thresholds (RMT) and intracortical inhibitory (short interval intracortical inhibition - SICI) and excitatory (intracortical facilitation - ICF) circuits' imbalance between the affected and non-affected motor cortices.
RESULTS
RESULTS
We observed a significant increase in RMT and SICI in the affected motor cortex (
CONCLUSION
CONCLUSIONS
This study extends current knowledge of functional weakness, arguing for a specific central nervous system abnormality which may be involved in the symptoms' pathophysiology.
Identifiants
pubmed: 32457588
doi: 10.3389/fnhum.2020.00153
pmc: PMC7220997
doi:
Types de publication
Journal Article
Langues
eng
Pagination
153Informations de copyright
Copyright © 2020 Benussi, Premi, Cantoni, Compostella, Magni, Gilberti, Vergani, Delrio, Gamba, Spezi, Costa, Tinazzi, Padovani, Borroni and Magoni.
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