Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.
HLA I and II
donor-specific antibodies
endothelial activation
transplant vasculopathy
vascular signaling
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
12
2019
accepted:
09
04
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Graft rejection remains the major obstacle after vascularized solid organ transplantation. Endothelial cells, which form the interface between the transplanted graft and the host's immunity, are the first target for host immune cells. During acute cellular rejection endothelial cells are directly attacked by HLA I and II-recognizing NK cells, macrophages, and T cells, and activation of the complement system leads to endothelial cell lysis. The established forms of immunosuppressive therapy provide effective treatment options, but the treatment of chronic rejection of solid organs remains challenging. Chronic rejection is mainly based on production of donor-specific antibodies that induce endothelial cell activation-a condition which phenotypically resembles chronic inflammation. Activated endothelial cells produce chemokines, and expression of adhesion molecules increases. Due to this pro-inflammatory microenvironment, leukocytes are recruited and transmigrate from the bloodstream across the endothelial monolayer into the vessel wall. This mononuclear infiltrate is a hallmark of transplant vasculopathy. Furthermore, expression profiles of different cytokines serve as clinical markers for the patient's outcome. Besides their effects on immune cells, activated endothelial cells support the migration and proliferation of vascular smooth muscle cells. In turn, muscle cell recruitment leads to neointima formation followed by reduction in organ perfusion and eventually results in tissue injury. Activation of endothelial cells involves antibody ligation to the surface of endothelial cells. Subsequently, intracellular signaling pathways are initiated. These signaling cascades may serve as targets to prevent or treat adverse effects in antibody-activated endothelial cells. Preventive or therapeutic strategies for chronic rejection can be investigated in sophisticated mouse models of transplant vasculopathy, mimicking interactions between immune cells and endothelium.
Identifiants
pubmed: 32457653
doi: 10.3389/fphys.2020.00443
pmc: PMC7227440
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
443Informations de copyright
Copyright © 2020 Kummer, Zaradzki, Vijayan, Arif, Weigand, Immenschuh, Wagner and Larmann.
Références
Front Immunol. 2013 Jun 10;4:138
pubmed: 23772226
Transplantation. 2006 Jul 15;82(1):108-12
pubmed: 16861949
J Am Soc Nephrol. 2012 Apr;23(4):750-63
pubmed: 22302197
Am J Transplant. 2009 Nov;9(11):2607-14
pubmed: 19843036
Am J Transplant. 2007 Jan;7(1):57-65
pubmed: 17227558
Transplantation. 2002 Jun 15;73(11):1846-8
pubmed: 12085014
Annu Rev Pathol. 2009;4:19-47
pubmed: 18717641
J Urol. 2009 Sep;182(3):1222-5
pubmed: 19625062
Cardiovasc Res. 2014 Mar 1;101(3):400-10
pubmed: 24323314
Pharmacol Rev. 2016 Apr;68(2):357-418
pubmed: 26956245
J Exp Med. 2009 Nov 23;206(12):2795-808
pubmed: 19887395
Nat Rev Immunol. 2012 Nov;12(11):786-98
pubmed: 23059428
J Am Soc Nephrol. 2002 Jan;13(1):234-41
pubmed: 11752043
Ann Surg. 1985 Feb;201(2):142-57
pubmed: 3882063
J Am Soc Nephrol. 2017 Feb;28(2):400-406
pubmed: 27798244
J Heart Lung Transplant. 2001 Apr;20(4):385-92
pubmed: 11295575
Sci Rep. 2018 Mar 26;8(1):5220
pubmed: 29581529
Transplant Proc. 2017 Jul - Aug;49(6):1461-1466
pubmed: 28736024
Transplantation. 2000 Jun 27;69(12):2515-24
pubmed: 10910271
J Card Fail. 2019 Feb;25(2):97-104
pubmed: 30543947
Immunol Res. 1993;12(3):258-75
pubmed: 7507156
Liver Transpl. 2017 Jun;23(6):804-812
pubmed: 28187520
Am J Transplant. 2014 Apr;14(4):806-19
pubmed: 24580843
J Heart Lung Transplant. 2004 Sep;23(9 Suppl):S217-22
pubmed: 15381167
Chin Med J (Engl). 2019 Apr 20;132(8):963-975
pubmed: 30958439
Nat Med. 1997 Feb;3(2):196-204
pubmed: 9018239
Transplant Proc. 2001 Feb-Mar;33(1-2):311
pubmed: 11266833
Am J Transplant. 2010 Aug;10(8):1812-22
pubmed: 20659089
World J Transplant. 2016 Sep 24;6(3):451-9
pubmed: 27683626
Hum Immunol. 2011 Dec;72(12):1150-9
pubmed: 22001078
Am J Transplant. 2009 Nov;9(11):2459-65
pubmed: 19775314
BMC Immunol. 2004 Mar 16;5:5
pubmed: 15113397
Xenotransplantation. 2015 Sep-Oct;22(5):391-8
pubmed: 26381495
Curr Opin Organ Transplant. 2009 Aug;14(4):414-8
pubmed: 19610173
Nat Biotechnol. 2019 Oct;37(10):1163-1173
pubmed: 31451733
Curr Vasc Pharmacol. 2003 Mar;1(1):1-9
pubmed: 15320847
J Immunol. 2017 Jun 15;198(12):4837-4845
pubmed: 28500075
Transplantation. 2007 Dec 15;84(11):1500-6
pubmed: 18091527
Dev Reprod. 2019 Jun;23(2):79-92
pubmed: 31321348
J Cell Biol. 2001 May 28;153(5):933-46
pubmed: 11381080
Am J Hypertens. 2008 May;21(5):587-91
pubmed: 18437152
Nature. 2003 Feb 13;421(6924):748-53
pubmed: 12610627
J Biol Chem. 2004 Feb 27;279(9):7370-7
pubmed: 14660645
Plast Reconstr Surg. 2006 Mar;117(3):836-44
pubmed: 16525274
Am J Transplant. 2012 Feb;12(2):313-21
pubmed: 22070565
Transplantation. 1997 Oct 27;64(8):1192-7
pubmed: 9355839
Circ J. 2010 Feb;74(2):233-9
pubmed: 20009354
Nat Rev Immunol. 2015 Nov;15(11):692-704
pubmed: 26471775
Clin Exp Immunol. 2008 Nov;154(2):270-84
pubmed: 18785974
Cytokine Growth Factor Rev. 2015 Jun;26(3):311-27
pubmed: 25498524
Transplantation. 2017 Apr;101(4):e75-e85
pubmed: 28045880
Am J Transplant. 2006 Oct;6(10):2488-96
pubmed: 16889597
J Heart Lung Transplant. 1996 Dec;15(12):1233-47
pubmed: 8981209
Circulation. 2019 Jan 22;139(4):502-517
pubmed: 30586708
Cell Rep. 2017 Jan 31;18(5):1256-1269
pubmed: 28147279
PLoS One. 2017 Jul 7;12(7):e0180281
pubmed: 28686641
Transplant Proc. 1991 Feb;23(1 Pt 1):205-7
pubmed: 1990513
Nat Rev Immunol. 2005 Oct;5(10):807-17
pubmed: 16175181
Transplantation. 2004 Dec 27;78(12):1729-39
pubmed: 15614145
Thromb Haemost. 2014 Jun;111(6):1077-88
pubmed: 24500083
Circ Res. 2006 Oct 13;99(8):801-15
pubmed: 17038650
Innov Surg Sci. 2017 Aug 08;2(4):171-187
pubmed: 31579751
N Engl J Med. 1969 Apr 3;280(14):735-9
pubmed: 4886455
Transplant Rev (Orlando). 2012 Apr;26(2):73-87
pubmed: 22074784
J Pathol. 2008 Jan;214(2):199-210
pubmed: 18161745
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Thromb Haemost. 2015 Jun;113(6):1312-22
pubmed: 25740465
Science. 2004 Apr 2;304(5667):104-7
pubmed: 15064419
Kidney Int. 2009 Apr;75(7):719-26
pubmed: 19177155
Pathology. 1998 Feb;30(1):24-9
pubmed: 9534204
J Biol Chem. 2008 Jan 18;283(3):1324-33
pubmed: 17981798
J Immunol. 2005 May 15;174(10):6477-89
pubmed: 15879151
Am J Transplant. 2005 Jun;5(6):1490-4
pubmed: 15888059
J Immunol. 2007 Jun 15;178(12):7911-22
pubmed: 17548629
Transplantation. 2012 Feb 27;93(4):364-72
pubmed: 22273841
J Exp Med. 2015 Oct 19;212(11):1883-99
pubmed: 26392222
Am J Transplant. 2003 Jun;3(6):708-14
pubmed: 12780562
Blood. 2002 Nov 1;100(9):3175-82
pubmed: 12384415
Am J Transplant. 2016 May;16(5):1559-68
pubmed: 26614396
Chest. 1996 Aug;110(2):559-62
pubmed: 8697867
S Afr Med J. 1975 Mar 1;49(9):303-12
pubmed: 1090016
J Immunol. 2000 Jun 15;164(12):6487-94
pubmed: 10843706
Circulation. 2006 Oct 10;114(15):1599-607
pubmed: 17015796
J Am Soc Nephrol. 2010 Nov;21(11):1878-90
pubmed: 20847143
Plast Reconstr Surg. 2015 Feb;135(2):488-99
pubmed: 25626795
J Am Soc Nephrol. 2019 Apr;30(4):692-709
pubmed: 30850439
J Exp Med. 2008 Dec 22;205(13):3145-58
pubmed: 19075290
Hum Immunol. 1997 Mar;53(1):90-7
pubmed: 9127152
Microvasc Res. 2018 Mar;116:34-44
pubmed: 28993199
J Biol Chem. 2009 May 1;284(18):12541-9
pubmed: 19265198
Nephrol Dial Transplant. 2013 Dec;28(12):3101-9
pubmed: 24081856
Am J Pathol. 1977 Jan;86(1):183-276
pubmed: 64118
J Cell Sci. 1997 Mar;110 ( Pt 5):583-8
pubmed: 9092940
Nat Rev Mol Cell Biol. 2003 May;4(5):397-407
pubmed: 12728273
Carcinogenesis. 2011 Jan;32(1):2-9
pubmed: 20952513
Ann Thorac Surg. 2004 Mar;77(3):1056-62
pubmed: 14992926
Transplantation. 2000 Jun 27;69(12):2658-62
pubmed: 10910290
Br J Anaesth. 2012 Jan;108 Suppl 1:i96-107
pubmed: 22194439
Nat Rev Immunol. 2012 May 25;12(6):459-71
pubmed: 22627862
Am J Transplant. 2016 May;16(5):1408-20
pubmed: 26614587
Am J Transplant. 2013 Feb;13(2):299-311
pubmed: 23279566
Nefrologia. 2014;34(5):570-8
pubmed: 25259811
J Heart Lung Transplant. 2002 Sep;21(9):971-5
pubmed: 12231367
Am J Transplant. 2016 Feb;16(2):389-97
pubmed: 26588186
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2577-81
pubmed: 11226281
Am J Respir Crit Care Med. 2016 Sep 1;194(5):596-606
pubmed: 26967790
Am J Transplant. 2001 Sep;1(3):260-9
pubmed: 12102260
Transplant Rev (Orlando). 2012 Apr;26(2):60-72
pubmed: 22000662
J Clin Invest. 2000 Jan;105(1):35-44
pubmed: 10619859
Transpl Immunol. 2015 Oct;33(2):95-102
pubmed: 26297861
J Biol Chem. 2006 Jul 14;281(28):19009-18
pubmed: 16670089
Kidney Int. 1999 Oct;56(4):1551-9
pubmed: 10504507
Annu Rev Pathol. 2017 Jan 24;12:187-215
pubmed: 27959627
Eur J Cardiothorac Surg. 2016 Jan;49(1):348-9
pubmed: 25724904
J Immunol. 2004 Oct 15;173(8):4828-37
pubmed: 15470023
Kidney Int. 2005 Dec;68(6):2621-8
pubmed: 16316338
Semin Immunol. 2012 Apr;24(2):115-21
pubmed: 22051115
Kidney Int. 2016 Aug;90(2):280-288
pubmed: 27188505
J Immunol. 2018 Apr 1;200(7):2372-2390
pubmed: 29475988
Am J Transplant. 2012 Mar;12(3):563-70
pubmed: 22300494
Transplantation. 2016 Jan;100(1):103-10
pubmed: 26262503
Kidney Int. 2011 Feb;79(3):288-99
pubmed: 20927041
J Clin Invest. 2005 May;115(5):1150-62
pubmed: 15864347
J Exp Med. 1993 Aug 1;178(2):449-60
pubmed: 8340753
PLoS One. 2016 Feb 29;11(2):e0148881
pubmed: 26928779
Transplantation. 2013 Aug 15;96(3):258-66
pubmed: 23823649
J Immunol. 2012 Jun 15;188(12):6287-99
pubmed: 22566565
Mediators Inflamm. 2010;2010:425191
pubmed: 21274265
J Infect Dis. 2013 Nov;208 Suppl 2:S125-30
pubmed: 24151318
J Immunol. 2013 Jun 15;190(12):6635-50
pubmed: 23690477
Transplantation. 2003 Jun 27;75(12):2001-7
pubmed: 12829901
J Thorac Cardiovasc Surg. 2009 Sep;138(3):752-9
pubmed: 19698866
Am J Transplant. 2010 Mar;10(3):510-7
pubmed: 20055805
Lancet. 2005 Apr 30-May 6;365(9470):1570-6
pubmed: 15866311
J Pharmacol Sci. 2016 May;131(1):6-12
pubmed: 26320674
Diving Hyperb Med. 2017 Jun;47(2):110-117
pubmed: 28641323
Transplantation. 2011 Jun 15;91(11):1218-26
pubmed: 21617586
Int J Mol Sci. 2019 Jun 27;20(13):
pubmed: 31252520
Circ Res. 2007 Feb 2;100(2):191-203
pubmed: 17272820
J Heart Lung Transplant. 2004 Sep;23(9 Suppl):S223-6
pubmed: 15381168
EMBO Rep. 2004 Aug;5(8):825-30
pubmed: 15272298
J Am Soc Nephrol. 1999 Oct;10(10):2208-14
pubmed: 10505698
Transplantation. 1990 Oct;50(4):537-44
pubmed: 2219269
Transplantation. 1998 Jun 27;65(12):1533-42
pubmed: 9665067
J Immunol. 2008 Feb 15;180(4):2214-24
pubmed: 18250428
Nat Med. 1998 Sep;4(9):1073-7
pubmed: 9734404
Transplant Rev (Orlando). 2014 Jul;28(3):103-10
pubmed: 24636846
J Cell Physiol. 2011 Apr;226(4):1035-43
pubmed: 20857419
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):133-138
pubmed: 29255056
Immunol Today. 1999 Oct;20(10):434-7
pubmed: 10500288
J Heart Lung Transplant. 2002 Jul;21(7):804-11
pubmed: 12100907
Mediators Inflamm. 2014;2014:694312
pubmed: 24803742
Transplantation. 1998 Dec 27;66(12):1786-92
pubmed: 9884277
Immunology. 2003 Jun;109(2):185-96
pubmed: 12757613
Cell Death Dis. 2019 Mar 8;10(3):235
pubmed: 30850581
Ann Transl Med. 2018 Oct;6(20):409
pubmed: 30498736
Circ Res. 2006 Feb 17;98(3):394-402
pubmed: 16385081
Anaesthesia. 2014 Jul;69(7):777-84
pubmed: 24773303
J Am Coll Cardiol. 2004 Mar 3;43(5):806-10
pubmed: 14998621
Circulation. 2003 Apr 22;107(15):1958-61
pubmed: 12695288
Circ Res. 2005 Apr 29;96(8):881-9
pubmed: 15774854
N Engl J Med. 2005 Feb 10;352(6):558-69
pubmed: 15703421
N Engl J Med. 2007 Sep 27;357(13):1293-300
pubmed: 17898098
Kidney Int. 2016 Jul;90(1):123-34
pubmed: 27236750
Transplantation. 2012 Feb 27;93(4):390-7
pubmed: 22222784
J Clin Oncol. 2007 Mar 1;25(7):884-96
pubmed: 17327610
Trends Immunol. 2003 Jun;24(6):327-34
pubmed: 12810109
J Immunol. 1995 Aug 1;155(3):1151-64
pubmed: 7636184
Nat Rev Nephrol. 2016 Aug;12(8):484-95
pubmed: 27345243
Nat Immunol. 2019 Jul;20(7):770-774
pubmed: 31160798
Front Immunol. 2018 May 14;9:972
pubmed: 29867953
Am J Physiol Cell Physiol. 2006 Dec;291(6):C1318-25
pubmed: 16855214
Am J Physiol Cell Physiol. 2001 Jun;280(6):C1475-84
pubmed: 11350743
Xenotransplantation. 2008 Jul-Aug;15(4):246-56
pubmed: 18957047
J Heart Lung Transplant. 2005 Nov;24(11):1906-14
pubmed: 16297799
Am J Transplant. 2007 Apr;7(4):864-71
pubmed: 17391129
Nat Commun. 2018 Jan 16;9(1):248
pubmed: 29339738
Front Immunol. 2014 Oct 21;5:505
pubmed: 25374567
Front Immunol. 2018 Oct 09;9:2310
pubmed: 30356754
J Immunol. 2002 Jun 1;168(11):5415-23
pubmed: 12023334
J Leukoc Biol. 2007 Jan;81(1):1-5
pubmed: 17032697
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4148-53
pubmed: 19251643
Eur J Cardiothorac Surg. 2013 Aug;44(2):201-6
pubmed: 23487534
Trends Mol Med. 2015 May;21(5):319-29
pubmed: 25801125
Hum Immunol. 2004 Apr;65(4):291-302
pubmed: 15120184
Cold Spring Harb Perspect Med. 2013 Nov 01;3(11):
pubmed: 24186491
J Biol Chem. 2001 Feb 9;276(6):4199-204
pubmed: 11054419
Immunobiology. 2013 Sep;218(9):1131-8
pubmed: 23642836
Kidney Int. 2019 Jul;96(1):189-201
pubmed: 31005275
Clin Epigenetics. 2018 May 22;10:67
pubmed: 29796118
PLoS One. 2015 Dec 21;10(12):e0145306
pubmed: 26690352
Curr Biol. 2004 Jul 27;14(14):1296-302
pubmed: 15268862
Am J Transplant. 2018 May;18(5):1096-1109
pubmed: 29045076
Am J Transplant. 2015 Aug;15(8):2050-61
pubmed: 25930666
J Exp Med. 2006 Aug 7;203(8):1851-8
pubmed: 16864660