Herpes Simplex Virus: The Hostile Guest That Takes Over Your Home.
apoptosis
autophagy
encephalitis
herpes
organelles
therapeutics
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
02
2020
accepted:
30
03
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Alpha (α)-herpesviruses (HSV-1 and HSV-2), like other viruses, are obligate intracellular parasites. They hijack the cellular machinery to survive and replicate through evading the defensive responses by the host. The viral genome of herpes simplex viruses (HSVs) contains viral genes, the products of which are destined to exploit the host apparatus for their own existence. Cellular modulations begin from the entry point itself. The two main gateways that the virus has to penetrate are the cell membrane and the nuclear membrane. Changes in the cell membrane are triggered when the glycoproteins of HSV interact with the surface receptors of the host cell, and from here, the components of the cytoskeleton take over. The rearrangement in the cytoskeleton components help the virus to enter as well as transport to the nucleus and back to the cell membrane to spread out to the other cells. The entire carriage process is also mediated by the motor proteins of the kinesin and dynein superfamily and is directed by the viral tegument proteins. Also, the virus captures the cell's most efficient cargo carrying system, the endoplasmic reticulum (ER)-Golgi vesicular transport machinery for egress to the cell membrane. For these reasons, the host cell has its own checkpoints where the normal functions are halted once a danger is sensed. However, a cell may be prepared for the adversities from an invading virus, and it is simply commendable that the virus has the antidote to these cellular strategies as well. The HSV viral proteins are capable of limiting the use of the transcriptional and translational tools for the cell itself, so that its own transcription and translation pathways remain unhindered. HSV prefers to constrain any self-destruction process of the cell-be it autophagy in the lysosome or apoptosis by the mitochondria, so that it can continue to parasitize the cell for its own survival. This review gives a detailed account of the significance of compartmentalization during HSV pathogenesis. It also highlights the undiscovered areas in the HSV cell biology research which demand attention for devising improved therapeutics against the infection.
Identifiants
pubmed: 32457704
doi: 10.3389/fmicb.2020.00733
pmc: PMC7221137
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
733Informations de copyright
Copyright © 2020 Banerjee, Kulkarni and Mukherjee.
Références
Rev Med Virol. 2000 Sep-Oct;10(5):305-19
pubmed: 11015742
J Gen Virol. 1997 Jan;78 ( Pt 1):83-9
pubmed: 9010289
Cold Spring Harb Perspect Biol. 2012 May 01;4(5):
pubmed: 22550233
J Virol. 2013 Jan;87(1):403-14
pubmed: 23077321
J Virol. 2014 Jul;88(13):7445-54
pubmed: 24741100
PLoS One. 2012;7(8):e42636
pubmed: 22900036
J Interferon Cytokine Res. 2009 Sep;29(9):599-607
pubmed: 19694546
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22260-5
pubmed: 21135248
J Virol. 2006 Aug;80(15):7354-63
pubmed: 16840316
Genes Dev. 2006 Feb 15;20(4):461-72
pubmed: 16481474
Curr Opin Cell Biol. 1993 Aug;5(4):628-35
pubmed: 8257604
J Virol. 2006 Nov;80(21):10565-78
pubmed: 16928747
F1000Res. 2017 Oct 5;6:1804
pubmed: 30135710
Genes Dev. 2010 Dec 1;24(23):2627-39
pubmed: 21123650
Acta Neuropathol. 2016 Sep;132(3):433-51
pubmed: 27457581
J Virol. 2014 Jun;88(11):6470-82
pubmed: 24672037
Front Cell Infect Microbiol. 2017 Aug 22;7:371
pubmed: 28879169
J Virol. 2005 Aug;79(15):9651-64
pubmed: 16014927
Cancer Metastasis Rev. 2014 Mar;33(1):115-41
pubmed: 24375388
J Virol. 2002 Sep;76(17):8939-52
pubmed: 12163613
J Virol. 2005 Jul;79(13):8348-60
pubmed: 15956580
Curr Eye Res. 2008 May;33(5):455-67
pubmed: 18568883
J Virol. 2010 Jul;84(13):6886-90
pubmed: 20427534
Biochem Soc Trans. 2008 Aug;36(Pt 4):701-7
pubmed: 18631144
Curr Opin Virol. 2014 Oct;8:54-61
pubmed: 25036916
Mol Cell Biol. 2010 Feb;30(3):781-92
pubmed: 19995918
Nat Microbiol. 2017 Nov;2(11):1543-1557
pubmed: 28871090
N Engl J Med. 1998 Jul 30;339(5):300-6
pubmed: 9696640
FEBS Lett. 2009 Dec 3;583(23):3804-10
pubmed: 19887068
J Gen Virol. 2006 Dec;87(Pt 12):3483-94
pubmed: 17098962
J Virol. 2017 Apr 28;91(10):
pubmed: 28275195
Hum Genomics. 2010 Jun;4(5):327-44
pubmed: 20650820
J Biol Chem. 2011 Jul 15;286(28):25406-15
pubmed: 21596749
J Cell Biol. 2015 Oct 26;211(2):323-37
pubmed: 26504169
Nat Cell Biol. 2014 Jun;16(6):495-501
pubmed: 24875736
Future Virol. 2015 Oct 1;10(10):1145-1154
pubmed: 27066105
Subcell Biochem. 2013;68:467-87
pubmed: 23737062
Virology. 2015 May;479-480:450-6
pubmed: 25858140
J Virol. 2013 Oct;87(20):11008-18
pubmed: 23903849
J Virol. 2014 Sep 1;88(17):9624-32
pubmed: 24920814
J Virol. 2014 Oct;88(19):11178-86
pubmed: 25031334
J Virol. 2007 Oct;81(19):10792-803
pubmed: 17652388
Br Med Bull. 1997;53(3):451-65
pubmed: 9374030
J Virol. 2015 Aug;89(15):7799-812
pubmed: 25995262
Annu Rev Cell Dev Biol. 2011;27:107-32
pubmed: 21801009
J Virol. 2006 Apr;80(7):3167-79
pubmed: 16537585
J Neurovirol. 2004 Jun;10(3):189-98
pubmed: 15204924
Trends Microbiol. 2005 Jul;13(7):320-7
pubmed: 15950476
Nature. 2007 Nov 29;450(7170):695-701
pubmed: 18046406
J Gen Virol. 1997 Feb;78 ( Pt 2):435-43
pubmed: 9018067
Cell Microbiol. 2013 Feb;15(2):170-8
pubmed: 23057731
Pflugers Arch. 2004 Feb;447(5):532-42
pubmed: 14770310
J Virol. 2014 Jul;88(14):7806-17
pubmed: 24789779
J Cancer. 2019 May 21;10(10):2185-2193
pubmed: 31258722
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):355-60
pubmed: 15625115
J Virol. 2008 Apr;82(7):3538-45
pubmed: 18216091
J Virol. 2013 Jan;87(2):859-71
pubmed: 23115300
Methods Cell Biol. 1981;23:283-300
pubmed: 7035806
J Virol. 2013 Jan;87(1):94-109
pubmed: 23077305
J Allergy Clin Immunol. 2019 Feb;143(2):765-769.e7
pubmed: 30296527
J Virol. 1992 Oct;66(10):5999-6007
pubmed: 1527849
J Cancer. 2017 Feb 25;8(5):761-773
pubmed: 28382138
J Clin Invest. 2015 Nov 2;125(11):4269-80
pubmed: 26524593
J Virol. 2017 May 26;91(12):
pubmed: 28356536
J Virol. 2014 May;88(9):4657-67
pubmed: 24522907
Structure. 2013 Apr 2;21(4):501-15
pubmed: 23561633
Sci Rep. 2015 Apr 09;5:9730
pubmed: 25856282
J Virol. 2009 Sep;83(18):9131-9
pubmed: 19587058
J Virol. 2006 Sep;80(18):8970-80
pubmed: 16940509
J Gen Virol. 1988 Jun;69 ( Pt 6):1405-10
pubmed: 2838578
J Virol. 2012 Sep;86(17):9527-30
pubmed: 22740404
Gene. 2003 Aug 14;313:17-42
pubmed: 12957375
Rev Med Virol. 2008 Jan-Feb;18(1):35-51
pubmed: 17992661
Oncogene. 2008 Oct 27;27(50):6507-21
pubmed: 18955976
Virus Res. 1991 Mar;18(2-3):271-90
pubmed: 1645908
Curr Biol. 2003 Aug 5;13(15):R614-24
pubmed: 12906817
Invest Ophthalmol Vis Sci. 2013 Feb 05;54(2):1070-9
pubmed: 23341013
Cell Host Microbe. 2012 Sep 13;12(3):334-45
pubmed: 22980330
J Virol. 2005 Jan;79(2):1071-83
pubmed: 15613336
Nat Rev Microbiol. 2011 Oct 17;9(12):860-75
pubmed: 22002165
Cell Mol Life Sci. 2008 Jun;65(11):1653-68
pubmed: 18351291
Cells. 2019 May 27;8(5):
pubmed: 31137833
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4572-6
pubmed: 8643445
Immunity. 2012 Aug 24;37(2):223-34
pubmed: 22921120
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5863-8
pubmed: 20231454
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10187-92
pubmed: 17548810
Int Rev Immunol. 1999;18(5-6):429-48
pubmed: 10672495
Virol J. 2009 Apr 06;6:40
pubmed: 19348670
Science. 2011 Jul 8;333(6039):228-33
pubmed: 21617041
J Cell Death. 2013 Apr 09;6:1-16
pubmed: 25278776
J Virol. 1998 Jan;72(1):873-5
pubmed: 9420303
J Virol. 2013 Dec;87(23):12656-66
pubmed: 24049165
PLoS Pathog. 2006 Aug;2(8):e85
pubmed: 16933992
Sci Adv. 2019 Aug 14;5(8):eaax0780
pubmed: 31453334
J Biol Chem. 2004 Jul 2;279(27):28522-30
pubmed: 15117959
J Virol. 2002 Jun;76(12):5974-84
pubmed: 12021330
J Cell Biol. 2006 Sep 25;174(7):1009-21
pubmed: 17000878
Mol Gen Genet. 1997 Oct;256(3):320-7
pubmed: 9393457
J Immunol. 2003 Sep 15;171(6):3075-83
pubmed: 12960333
Viruses. 2016 Jun 07;8(6):
pubmed: 27338443
J Virol. 2007 Oct;81(19):10242-8
pubmed: 17634220
Curr Opin Cell Biol. 1992 Aug;4(4):600-8
pubmed: 1419041
Mol Biol Cell. 2001 Jul;12(7):2031-46
pubmed: 11452001
Virology. 2015 May;479-480:568-77
pubmed: 25798530
J Cell Physiol. 2012 May;227(5):1791-5
pubmed: 21732347
J Virol. 2000 Jan;74(1):117-29
pubmed: 10590098
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18773-84
pubmed: 16365312
J Virol. 2005 Jan;79(2):1191-206
pubmed: 15613346
Cell. 2005 Jan 28;120(2):159-62
pubmed: 15680321
Nat Cell Biol. 2000 Jun;2(6):326-32
pubmed: 10854322
J Virol. 2005 Jun;79(12):7609-16
pubmed: 15919913
Viruses. 2018 Feb 23;10(2):
pubmed: 29473915
J Virol. 2009 May;83(10):5181-91
pubmed: 19279109
J Virol. 2009 Mar;83(5):2058-66
pubmed: 18842724
mBio. 2013 Feb 26;4(2):
pubmed: 23443004
EMBO Rep. 2007 Feb;8(2):188-93
pubmed: 17186027
Mol Biol Cell. 2011 May;22(9):1529-38
pubmed: 21411625
J Biol Chem. 2007 Aug 17;282(33):24477-84
pubmed: 17597067
Lancet. 2001 May 12;357(9267):1513-8
pubmed: 11377626
Cell. 2004 Jan 23;116(2):153-66
pubmed: 14744428
J Clin Invest. 2001 Aug;108(4):503-10
pubmed: 11518721
J Cancer Res Clin Oncol. 2007 Feb;133(2):71-81
pubmed: 16941191
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2798-802
pubmed: 8385343
J Virol. 1988 Dec;62(12):4577-85
pubmed: 2846871
J Virol. 2006 May;80(9):4264-75
pubmed: 16611885
J Virol. 2018 Aug 16;92(17):
pubmed: 29925667
Cell Host Microbe. 2007 Mar 15;1(1):23-35
pubmed: 18005679
J Cell Sci. 2008 Jan 1;121(Pt 1):11-8
pubmed: 18096687
Nat Commun. 2011 Dec 06;2:577
pubmed: 22146396
Adv Virus Res. 2016;95:149-95
pubmed: 27112282
J Virol. 2007 Apr;81(7):3377-90
pubmed: 17229688
J Virol. 2001 Sep;75(18):8803-17
pubmed: 11507225
Curr Opin Cell Biol. 2000 Aug;12(4):445-9
pubmed: 10873822
Virol J. 2011 Oct 26;8:481
pubmed: 22029482
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):843-8
pubmed: 9023344
J Neurovirol. 2013 Aug;19(4):346-50
pubmed: 23775137
Nat Rev Microbiol. 2011 May;9(5):382-94
pubmed: 21494278
J Virol. 2004 Jun;78(11):5564-75
pubmed: 15140953
Virology. 2016 Nov;498:31-35
pubmed: 27543756
J Virol. 2013 May;87(10):5904-15
pubmed: 23487471
Biochem Cell Biol. 1986 Dec;64(12):1303-9
pubmed: 2436639
Virus Res. 2004 Dec;106(2):167-80
pubmed: 15567495
J Virol. 2009 Apr;83(7):3115-26
pubmed: 19158241
Biochem Biophys Res Commun. 2010 Jan 1;391(1):176-81
pubmed: 19909728
Virology. 2004 May 1;322(2):286-99
pubmed: 15110526
J Virol. 2008 Jan;82(2):617-29
pubmed: 17959661
J Gen Virol. 2000 Feb;81(Pt 2):401-6
pubmed: 10644838
Cell Rep. 2017 Jul 11;20(2):439-450
pubmed: 28700944
Antiviral Res. 2012 Dec;96(3):363-75
pubmed: 23047013
Nature. 2011 Jan 20;469(7330):323-35
pubmed: 21248839
Nature. 1999 Jan 21;397(6716):271-4
pubmed: 9930704
J Virol. 2000 Oct;74(19):8953-65
pubmed: 10982339
Science. 1975 Aug 1;189(4200):347-58
pubmed: 1096303
J Cell Biol. 2001 May 28;153(5):1011-22
pubmed: 11381086
Nat Rev Microbiol. 2011 May;9(5):369-81
pubmed: 21478902
Wiley Interdiscip Rev RNA. 2013 Nov-Dec;4(6):693-708
pubmed: 23900973
J Virol. 2005 Oct;79(20):13047-59
pubmed: 16189007
Immunology. 2002 Sep;107(1):129-35
pubmed: 12225371
Curr Eye Res. 2014 Jun;39(6):596-603
pubmed: 24401006
mBio. 2012 Jul 24;3(4):e00144-12
pubmed: 22829677
J Virol. 2015 Sep;89(17):8982-98
pubmed: 26085152
Virology. 2010 Oct 10;406(1):127-37
pubmed: 20674954
J Neurovirol. 2002 Dec;8 Suppl 2:103-11
pubmed: 12491160
J Virol. 2015 Feb;89(3):1932-8
pubmed: 25428865
Virus Res. 2006 Apr;117(1):90-104
pubmed: 16490275
Annu Rev Cell Dev Biol. 2002;18:575-99
pubmed: 12142265
Viruses. 2015 Jan 12;7(1):52-71
pubmed: 25588052
Rev Med Virol. 2010 Jul;20(4):214-30
pubmed: 20069615
Nat Rev Mol Cell Biol. 2012 Dec;13(12):780-8
pubmed: 23175281
Science. 2007 Nov 30;318(5855):1408-12
pubmed: 18048680
PLoS Pathog. 2018 Nov 26;14(11):e1007331
pubmed: 30475899
Nat Commun. 2015 Apr 27;6:6985
pubmed: 25912399
Pharmacol Res. 2015 Apr;94:9-25
pubmed: 25662515
J Virol. 2004 May;78(9):4684-99
pubmed: 15078951
J Virol. 2013 Mar;87(5):2857-67
pubmed: 23269794
J Am Acad Dermatol. 2007 Nov;57(5):737-63; quiz 764-6
pubmed: 17939933
J Virol. 2007 May;81(9):4429-37
pubmed: 17301149
Virology. 2007 Dec 5;369(1):12-8
pubmed: 17727910
Intern Med. 2002 Jun;41(6):420-8
pubmed: 12135172
Cell Struct Funct. 2011;36(2):145-54
pubmed: 21150131
Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27
pubmed: 20094052
Nat Immunol. 2009 May;10(5):480-7
pubmed: 19305394
Sci Transl Med. 2018 Feb 14;10(428):
pubmed: 29444978
Biochemistry. 2013 Apr 2;52(13):2319-27
pubmed: 23521171
Genes Dev. 2004 Mar 15;18(6):660-72
pubmed: 15075293
F1000Res. 2019 Feb 18;8:198
pubmed: 31249678
J Immunol. 1995 Oct 1;155(7):3585-92
pubmed: 7561057
Sci China Life Sci. 2016 Jul;59(7):656-72
pubmed: 27294833
Biochem Soc Trans. 2008 Dec;36(Pt 6):1339-43
pubmed: 19021552
PLoS One. 2012;7(10):e48147
pubmed: 23110193
Nature. 1997 Nov 6;390(6655):81-5
pubmed: 9363894
J Nanobiotechnology. 2018 Dec 11;16(1):102
pubmed: 30538002
J Virol. 2013 Apr;87(7):3990-7
pubmed: 23365427
Virus Res. 2006 Jul;119(1):89-99
pubmed: 16305812