Intravital Multiphoton Microscopy of the Ocular Surface: Alterations in Conventional Dendritic Cell Morphology and Kinetics in Dry Eye Disease.

Animals Cell Movement / immunology Dendritic Cells / immunology Disease Models, Animal Dry Eye Syndromes / diagnostic imaging Female Intravital Microscopy / methods Kinetics Limbus Corneae / diagnostic imaging Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Fluorescence, Multiphoton / methods Optic Nerve / immunology
conventional dendritic cells cornea dry eye disease intravital imaging limbus multiphoton microscopy ocular surface sensory nerves

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 07 08 2019
accepted: 01 04 2020
entrez: 28 5 2020
pubmed: 28 5 2020
medline: 1 4 2021
Statut: epublish

Résumé

Dry eye disease (DED) is a multifactorial disease of the ocular surface, characterized by loss of tear film homeostasis and ocular symptoms, in which neurosensory abnormalities have recently been shown to play an etiological role. Although the role of inflammation has been widely studied in DED, the kinetics of immune cells of the ocular surface in this complex disease are hereto unclear. Herein, we utilized intravital multiphoton imaging on transgenic mice to investigate the 3D morphology and kinetics of conventional dendritic cells (cDCs) and the role of ocular surface sensory nerves in regulating them in both the naïve state and experimental DED. Mice with DED had significantly lower tear secretion (

Identifiants

DOI: 10.3389/fimmu.2020.00742 PMID: 32457740 PMC: PMC7227427
pubmed: 32457740
doi: 10.3389/fimmu.2020.00742
pmc: PMC7227427
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

742

Subventions

Organisme : NEI NIH HHS
ID : R01 EY022695
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026963
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029602
Pays : United States

Informations de copyright

Copyright © 2020 Jamali, Seyed-Razavi, Chao, Ortiz, Kenyon, Blanco, Harris and Hamrah.

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Auteurs

Arsia Jamali (A)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Yashar Seyed-Razavi (Y)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Cecilia Chao (C)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Gustavo Ortiz (G)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Brendan Kenyon (B)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Program in Neuroscience, School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States.

Tomas Blanco (T)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Deshea L Harris (DL)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.

Pedram Hamrah (P)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.
Program in Neuroscience, School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States.
Program in Immunology, School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Maladies de l'oeil › Maladies de l'appareil lacrymal › Syndromes de l'oeil sec › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Techniques d'investigation › Microscopie intravitale › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cornée › Limbe de la cornée › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Techniques d'investigation › Microscopie optique non linéaire › Microscopie de fluorescence multiphotonique › Intravital Multiphoton Microscopy of the...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs crâniens › Nerf optique › Intravital Multiphoton Microscopy of the...