Causal Attributions in an Australian Aboriginal Family With Marfan Syndrome: A Qualitative Study.
Aboriginal Australian
Marfan syndrome
causal attribution
genetics
psychosocial
qualitative
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
12
2019
accepted:
14
04
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Causal attributions are important determinants of how health threats are processed and affect health-related behaviors. To date, there has been no research on causal attributions in genetic conditions in Aboriginal Australians. Forty members of a large Aboriginal Australian family with Marfan syndrome (MFS) were invited to participate in an ethically approved study exploring causal attributions, including perceived causes of phenotypic variability within the family. Eighteen individuals consented to conduct semi-structured qualitative interviews, which were recorded, transcribed verbatim and analyzed thematically. Most participants knew that MFS was genetic, but there were diverse theories about inheritance, including beliefs that it skipped generations, was affected by birth order and/or gender, and that it co-occurred with inheritance of blue eyes within this family. The mutation was thought to have been inherited from British settlers and initially triggered by disease or diet. Factors believed to modify disease severity included other genes and lifestyle factors, particularly alcohol and substance abuse and stress. Generally, this family did not endorse "blaming" chance or a higher power for phenotypic variability, though some felt that the spirits or a deity may have played a role. In conclusion, although participants knew MFS was a genetic condition, many speculated about the role of non-genetic causes in initiating the original mutation; and the gene-environment interaction was thought to affect severity. This study demonstrates a successful approach for exploring causal attributions in other genetic conditions in First Australians.
Identifiants
pubmed: 32457804
doi: 10.3389/fgene.2020.00461
pmc: PMC7221064
doi:
Types de publication
Journal Article
Langues
eng
Pagination
461Informations de copyright
Copyright © 2020 McInerney-Leo, West, Meiser, West, Brown and Duncan.
Références
J Genet Couns. 2006 Oct;15(5):325-37
pubmed: 16972194
Int J Palliat Nurs. 2006 Mar;12(3):102-8
pubmed: 16628174
Rural Remote Health. 2006 Jul-Sep;6(3):549
pubmed: 16831058
Hum Mol Genet. 2003 Sep 15;12(18):2269-76
pubmed: 12915484
Br J Clin Psychol. 1988 Feb;27(1):55-65
pubmed: 3281733
Am J Epidemiol. 2007 Apr 1;165(7):838-45
pubmed: 17215382
J Genet Couns. 2008 Aug;17(4):373-83
pubmed: 18607703
Aust J Rural Health. 2007 Aug;15(4):264-8
pubmed: 17617091
Lancet. 2005 Dec 3;366(9501):1965-76
pubmed: 16325700
Am J Med Genet. 1992 Feb 15;42(4):508-15
pubmed: 1535178
Sci Rep. 2016 Mar 01;6:22426
pubmed: 26927851
BMC Health Serv Res. 2016 May 13;16:178
pubmed: 27175475
Aust J Rural Health. 2003 Dec;11(6):260-5
pubmed: 14678407
Heart. 1999 Jul;82(1):19-22
pubmed: 10377302
Med J Aust. 2008 Nov 3;189(9):499-503
pubmed: 18976191
Aust N Z J Public Health. 2016 Dec;40(6):535-541
pubmed: 27523395
Am J Hum Genet. 2007 Feb;80(2):241-52
pubmed: 17236130
Clin Genet. 2004 Jan;65(1):66-9
pubmed: 15032979
J Behav Med. 2002 Aug;25(4):373-94
pubmed: 12136498
J Psychosom Res. 1998 May;44(5):573-85
pubmed: 9623878
Am J Med Genet. 1979;4(1):73-87
pubmed: 495655
BMC Health Serv Res. 2009 Jul 31;9:132
pubmed: 19643031
Med J Aust. 2014 Jun 16;200(11):623-4
pubmed: 24938332
Contemp Nurse. 2006 Sep;22(2):240-54
pubmed: 17026431
N Engl J Med. 1972 Apr 13;286(15):804-8
pubmed: 5011789
Clin Genet. 2001 Oct;60(4):273-82
pubmed: 11683773
Am Heart J. 2010 Aug;160(2):315-21
pubmed: 20691838
N Engl J Med. 2001 Aug 2;345(5):351-8
pubmed: 11484693
J Am Coll Cardiol. 2017 Aug 29;70(9):1148-1158
pubmed: 28838364
J Genet Couns. 1998 Feb;7(1):15-29
pubmed: 26141094
Circ Cardiovasc Interv. 2014 Oct;7(5):645-55
pubmed: 25294399
Med J Aust. 2015 Jun 1;202(10):S51-6
pubmed: 26017258
Soc Sci Med. 1989;28(9):945-56
pubmed: 2711229
Am J Med Genet. 1999 Jan 1;82(1):53-9
pubmed: 9916844
Eur J Oncol Nurs. 2009 Sep;13(4):280-6
pubmed: 19282240
J Abnorm Psychol. 1978 Feb;87(1):49-74
pubmed: 649856
Curr Probl Cardiol. 2008 Jan;33(1):7-39
pubmed: 18155514
J Med Genet. 2010 Jul;47(7):476-85
pubmed: 20591885
Health Educ Res. 2000 Apr;15(2):131-43
pubmed: 10751372
J Pers Soc Psychol. 1984 Mar;46(3):489-502
pubmed: 6707865
Health Care Women Int. 1999 Sep-Oct;20(5):505-15
pubmed: 10776119
Am J Hosp Palliat Care. 2007 Apr-May;24(2):105-13
pubmed: 17502434
Am J Hum Genet. 1995 Aug;57(2):431-8
pubmed: 7668270
Heart Lung Circ. 2007 Feb;16(1):28-30
pubmed: 17188935
Can J Ophthalmol. 1969 Apr;4(2):128-35
pubmed: 5769099
J Pers Soc Psychol. 1987 Aug;53(2):273-9
pubmed: 3625467
Cleft Palate J. 1990 Jul;27(3):294-300
pubmed: 2197040
J Clin Invest. 1992 May;89(5):1674-80
pubmed: 1569206
J Genet Couns. 2010 Oct;19(5):430-46
pubmed: 20512408
Nature. 1991 Jul 25;352(6333):330-4
pubmed: 1852206
Fam Process. 1989 Mar;28(1):59-68
pubmed: 2522897
Medicine (Baltimore). 1958 Sep;37(3):217-79
pubmed: 13577293
N Engl J Med. 2008 Jun 26;358(26):2787-95
pubmed: 18579813
J Community Genet. 2014 Oct;5(4):399-407
pubmed: 25026992
Hum Mol Genet. 2015 May 15;24(10):2764-70
pubmed: 25652400
Hum Mol Genet. 1995;4 Spec No:1799-809
pubmed: 8541880
Aust Nurs J. 2006 Mar;13(8):27
pubmed: 16544686
Am J Cardiol. 1984 Mar 1;53(6):849-55
pubmed: 6702637