Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase.
AMPK
BAT
WAT
adipogenesis
beige/brite adipocytes
obesity
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
02
2020
accepted:
03
04
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
28
5
2020
Statut:
epublish
Résumé
Obesity is now a widespread disorder, and its prevalence has become a critical concern worldwide, due to its association with common co-morbidities like cancer, cardiovascular diseases and diabetes. Adipose tissue is an endocrine organ and therefore plays a critical role in the survival of an individual, but its dysfunction or excess is directly linked to obesity. The journey from multipotent mesenchymal stem cells to the formation of mature adipocytes is a well-orchestrated program which requires the expression of several genes, their transcriptional factors, and signaling intermediates from numerous pathways. Understanding all the intricacies of adipogenesis is vital if we are to counter the current epidemic of obesity because the limited understanding of these intricacies is the main barrier to the development of potent therapeutic strategies against obesity. In particular, AMP-Activated Protein Kinase (AMPK) plays a crucial role in regulating adipogenesis - it is arguably the central cellular energy regulation protein of the body. Since AMPK promotes the development of brown adipose tissue over that of white adipose tissue, special attention has been given to its role in adipose tissue development in recent years. In this review, we describe the molecular mechanisms involved in adipogenesis, the role of signaling pathways and the substantial role of activated AMPK in the inhibition of adiposity, concluding with observations which will support the development of novel chemotherapies against obesity epidemics.
Identifiants
pubmed: 32457917
doi: 10.3389/fmolb.2020.00076
pmc: PMC7226927
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
76Informations de copyright
Copyright © 2020 Ahmad, Serpell, Fong and Wong.
Références
Exp Mol Med. 2016 Jul 15;48(7):e245
pubmed: 27416781
Arch Med Sci. 2013 Apr 20;9(2):191-200
pubmed: 23671428
Stem Cells. 2009 Mar;27(3):703-13
pubmed: 19096040
Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1560-8
pubmed: 22454291
Science. 2012 May 18;336(6083):918-22
pubmed: 22517326
J Biol Chem. 2004 Feb 6;279(6):4471-8
pubmed: 14593102
Anat Histol Embryol. 2006 Aug;35(4):271-8
pubmed: 16836593
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a008417
pubmed: 22952395
Int J Endocrinol. 2018 Jul 10;2018:2014192
pubmed: 30123258
Pharm Regul Aff. 2014 Jul;3(2):
pubmed: 27478687
Cell Res. 2010 Apr;20(4):434-44
pubmed: 20101261
Diabetes. 2006 Oct;55(10):2797-804
pubmed: 17003345
Cell Biosci. 2015 Jun 10;5:28
pubmed: 26085920
J Biol Chem. 2005 Jul 1;280(26):25250-7
pubmed: 15878856
Int J Mol Sci. 2018 Jan 25;19(2):
pubmed: 29370110
Diabetes. 2002 Apr;51(4):1035-41
pubmed: 11916923
Mol Nutr Food Res. 2016 Jan;60(1):18-42
pubmed: 26201764
Trends Cell Biol. 2017 Sep;27(9):658-672
pubmed: 28552280
J Physiol. 2006 Jul 1;574(Pt 1):55-62
pubmed: 16709632
J Diabetes Res. 2018 Mar 11;2018:9256482
pubmed: 29713651
Genes Dev. 2009 Apr 1;23(7):788-97
pubmed: 19339685
Diabetes. 2011 Jan;60(1):168-76
pubmed: 20956498
J Biol Chem. 2003 Jan 24;278(4):2581-4
pubmed: 12426306
Trends Mol Med. 2015 Sep;21(9):571-9
pubmed: 26271143
Scientifica (Cairo). 2013;2013:684736
pubmed: 24416618
Obesity (Silver Spring). 2019 Jan;27(1):13-21
pubmed: 30569639
Cell Rep. 2019 Nov 5;29(6):1511-1523.e5
pubmed: 31693892
Biochem Biophys Res Commun. 2008 Sep 5;373(4):545-9
pubmed: 18586010
Mo Med. 2014 Jan-Feb;111(1):65-72
pubmed: 24645302
Mol Cell Endocrinol. 2017 Jan 15;440:44-56
pubmed: 27840174
Int J Mol Sci. 2018 Nov 09;19(11):
pubmed: 30423971
Mol Cell Biol. 2005 Jan;25(2):706-15
pubmed: 15632071
Front Physiol. 2018 Feb 21;9:122
pubmed: 29515462
News Physiol Sci. 2002 Jun;17:99-104
pubmed: 12021379
Mol Cell Biol. 2007 Jun;27(12):4347-54
pubmed: 17403895
Exp Mol Med. 2016 Apr 01;48:e224
pubmed: 27034026
Molecules. 2016 Sep 23;21(10):
pubmed: 27669202
Stem Cells. 2008 Apr;26(4):1037-46
pubmed: 18258719
Am J Physiol Cell Physiol. 2000 Sep;279(3):C670-81
pubmed: 10942717
J Endocrinol. 2019 May 10;241(3):R97-R109
pubmed: 31144796
Endocrinol Metab Clin North Am. 2012 Jun;41(2):283-95, v-vi
pubmed: 22682631
Growth Factors. 2004 Dec;22(4):233-41
pubmed: 15621726
Cell Metab. 2006 Jan;3(1):25-34
pubmed: 16399502
J Hepatol. 2014 Dec;61(6):1365-75
pubmed: 25048951
J Food Drug Anal. 2017 Jan;25(1):100-110
pubmed: 28911527
Front Endocrinol (Lausanne). 2016 Mar 02;7:19
pubmed: 26973598
Endocrinology. 2013 Sep;154(9):2992-3000
pubmed: 23782940
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4112-7
pubmed: 15024128
Obes Rev. 2017 Feb;18 Suppl 1:65-81
pubmed: 28164456
Nat Med. 2015 Feb;21(2):166-72
pubmed: 25485911
J Lipid Res. 2012 Apr;53(4):792-801
pubmed: 22323564
Calcif Tissue Int. 2006 Sep;79(3):169-78
pubmed: 16969589
Annu Rev Biochem. 2012;81:715-36
pubmed: 22463691
Nature. 2008 Aug 21;454(7207):1000-4
pubmed: 18719589
Can J Physiol Pharmacol. 2011 Nov;89(11):793-9
pubmed: 22017765
Eur J Nutr. 2019 Feb;58(1):5-25
pubmed: 29541908
Trends Endocrinol Metab. 2009 Apr;20(3):107-14
pubmed: 19269847
J Cell Sci. 2001 Jun;114(Pt 11):2085-94
pubmed: 11493644
Int J Biol Sci. 2008 Jan 26;4(1):29-36
pubmed: 18274621
J Clin Invest. 2006 May;116(5):1202-9
pubmed: 16670761
Horm Mol Biol Clin Investig. 2015 Jan;21(1):57-74
pubmed: 25781552
Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96
pubmed: 17139329
Cell Death Differ. 2012 Dec;19(12):1917-27
pubmed: 22722334
J Biol Chem. 2015 Jan 9;290(2):755-61
pubmed: 25451943
Stem Cell Rev Rep. 2018 Feb;14(1):27-42
pubmed: 29027120
Nat Commun. 2018 Nov 26;9(1):4974
pubmed: 30478315
Sci Rep. 2017 Jan 13;7:40445
pubmed: 28084425
Front Physiol. 2019 Jan 28;9:1973
pubmed: 30745884
Gerontology. 2012;58(1):15-23
pubmed: 21135534
Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1244-53
pubmed: 20354155
Diabetes. 2012 May;61(5):1217-24
pubmed: 22447857
Nat Rev Mol Cell Biol. 2019 Apr;20(4):242-258
pubmed: 30610207
J Clin Invest. 2019 Oct 1;129(10):3990-4000
pubmed: 31573548
Endocr Rev. 2013 Jun;34(3):413-38
pubmed: 23550082
Int J Obes (Lond). 2015 Jun;39(6):967-76
pubmed: 25761413
Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1160-1171
pubmed: 29409985
Autophagy. 2015;11(8):1341-57
pubmed: 26103054
Clin Sci (Lond). 2013 Apr;124(8):491-507
pubmed: 23298225
Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9635-40
pubmed: 22645355
J Biol Chem. 2006 Sep 1;281(35):25336-43
pubmed: 16835226
Nutrients. 2015 Sep 22;7(9):8152-69
pubmed: 26402699
JACC Basic Transl Sci. 2018 Feb;3(1):132-156
pubmed: 29876529
FEBS Lett. 2008 Sep 22;582(21-22):3201-5
pubmed: 18708054
J Clin Invest. 2009 Nov;119(11):3329-39
pubmed: 19855132
J Biol Chem. 2004 Aug 20;279(34):35503-9
pubmed: 15190075
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2058-63
pubmed: 14769942
Biochem Biophys Res Commun. 2009 Sep 11;387(1):207-11
pubmed: 19577541
Am J Physiol Cell Physiol. 2014 Mar 1;306(5):C431-40
pubmed: 24284793
Mol Biol Cell. 2011 Jul 1;22(13):2165-74
pubmed: 21562223
Biochem Biophys Res Commun. 2005 May 6;330(2):505-10
pubmed: 15796911
Compr Physiol. 2018 Dec 13;9(1):1-58
pubmed: 30549014
J R Soc Interface. 2018 Jan;15(138):
pubmed: 29343628
Nat Med. 2013 Oct;19(10):1252-63
pubmed: 24100998
Diabetes Metab Syndr Obes. 2014 Jun 24;7:241-53
pubmed: 25018645
Mol Med. 2011 Sep-Oct;17(9-10):1022-30
pubmed: 21647536
Curr Diab Rep. 2018 Aug 17;18(10):80
pubmed: 30120579
Diabetes. 2013 Jun;62(6):1923-31
pubmed: 23315497
Nature. 2009 Aug 27;460(7259):1154-8
pubmed: 19641492
Trends Endocrinol Metab. 2012 Mar;23(3):125-32
pubmed: 22284532
PLoS One. 2016 Sep 09;11(9):e0162238
pubmed: 27611969
Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E172-83
pubmed: 25406261
Chem Biol. 2008 Nov 24;15(11):1220-30
pubmed: 19022182
Mol Cell. 1999 Oct;4(4):585-95
pubmed: 10549290
Nature. 2006 Nov 16;444(7117):337-42
pubmed: 17086191
Biochim Biophys Acta. 2010 Mar;1804(3):581-91
pubmed: 19778642
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Endocrinology. 2010 Mar;151(3):980-92
pubmed: 20133456
Cell Metab. 2016 Jul 12;24(1):118-29
pubmed: 27411013
Diabetes. 2003 Jun;52(6):1355-63
pubmed: 12765944
Nat Commun. 2013;4:3017
pubmed: 24352254
Diabetes. 2015 Jul;64(7):2369-75
pubmed: 26050669
Int J Mol Sci. 2016 Jan 19;17(1):
pubmed: 26797605
Biol Pharm Bull. 2009 Jun;32(6):993-8
pubmed: 19483304
Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R936-44
pubmed: 12626360
Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1075-E1085
pubmed: 30253109
Biol Pharm Bull. 2018 Jul 1;41(7):985-993
pubmed: 29709897
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4401-6
pubmed: 17360536
Nat Med. 2015 Apr;21(4):389-94
pubmed: 25774848
J Clin Med. 2019 Jun 14;8(6):
pubmed: 31208019
Mol Cell Biol. 2007 Jul;27(13):4698-707
pubmed: 17452443
J Mol Endocrinol. 2011 Jan 19;46(1):21-8
pubmed: 21062936
Endocr Rev. 2011 Jun;32(3):387-403
pubmed: 21173384
Kidney Res Clin Pract. 2016 Jun;35(2):69-77
pubmed: 27366660
J Cell Biol. 2002 Oct 14;159(1):135-46
pubmed: 12379805
Biochem J. 2009 Dec 14;425(1):215-23
pubmed: 19811452
Biomaterials. 2014 Mar;35(10):3172-9
pubmed: 24439409
J Intern Med. 2016 Nov;280(5):465-475
pubmed: 27699898
Bone. 2012 Feb;50(2):477-89
pubmed: 21872687
Cytokine. 2013 Oct;64(1):138-45
pubmed: 23911203
J Physiol. 2007 Apr 15;580(Pt. 2):677-84
pubmed: 17272339
J Agric Food Chem. 2011 Dec 28;59(24):13346-52
pubmed: 22098587
J Biol Chem. 2010 Mar 5;285(10):7153-64
pubmed: 20028987
J Cell Sci. 2011 Aug 15;124(Pt 16):2681-6
pubmed: 21807935
Nat Commun. 2016 Jul 27;7:12205
pubmed: 27461402
PLoS One. 2013 Jul 26;8(7):e70135
pubmed: 23922935
Int J Biochem Cell Biol. 2012 Mar;44(3):475-9
pubmed: 22226816
Diab Vasc Dis Res. 2018 Jan;15(1):3-13
pubmed: 29113510
Cell Metab. 2013 Apr 2;17(4):562-74
pubmed: 23499423
Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2569-78
pubmed: 19755644
J Biol. 2003;2(4):28
pubmed: 14511394
EMBO J. 2009 Mar 18;28(6):677-85
pubmed: 19197243
Diabetes. 2015 May;64(5):1544-54
pubmed: 25475439
Obesity (Silver Spring). 2014 Mar;22(3):730-8
pubmed: 23963743
Mol Cell Biol. 2008 Jun;28(12):3967-78
pubmed: 18391014
Circulation. 2012 Jun 5;125(22):2782-91
pubmed: 22665886
Eur J Cell Biol. 2013 Jun-Jul;92(6-7):229-36
pubmed: 23876739
Expert Opin Ther Targets. 2009 Feb;13(2):235-46
pubmed: 19236241
Mol Aspects Med. 2019 Aug;68:74-81
pubmed: 31228478
Mol Cell. 1999 Oct;4(4):611-7
pubmed: 10549292
Mol Cell Biol. 2005 Feb;25(4):1272-82
pubmed: 15684380
J Nutr. 2009 May;139(5):919-25
pubmed: 19297423
J Clin Invest. 2006 Jun;116(6):1494-505
pubmed: 16691291
Cell. 2013 Jan 17;152(1-2):290-303
pubmed: 23332761
Cell Rep. 2019 Apr 30;27(5):1528-1540.e7
pubmed: 31042478
Diabetes. 2003 Sep;52(9):2205-12
pubmed: 12941758
J Biol Chem. 2004 Aug 20;279(34):36093-102
pubmed: 15190061
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18011-6
pubmed: 16326804
Nature. 2010 Aug 26;466(7310):1110-4
pubmed: 20686481
Mol Endocrinol. 2006 Apr;20(4):844-56
pubmed: 16339272
Trends Endocrinol Metab. 2014 Jun;25(6):293-302
pubmed: 24793638
Cell Metab. 2012 Sep 5;16(3):348-62
pubmed: 22940198
Biochem Biophys Res Commun. 2001 Sep 7;286(5):852-6
pubmed: 11527376
Front Horm Res. 2008;36:198-211
pubmed: 18230904
Mol Cell. 2015 Jan 22;57(2):235-46
pubmed: 25578880
Eur J Clin Invest. 2018 Sep;48(9):e12997
pubmed: 29995306
Mol Cell Biol. 2003 Oct;23(20):7230-42
pubmed: 14517293
FEBS Lett. 2003 Jul 3;546(1):113-20
pubmed: 12829246
Nat Metab. 2019 Mar;1(3):340-349
pubmed: 30887000
Diabetes. 2004 Apr;53(4):1052-9
pubmed: 15047621
Trends Endocrinol Metab. 2017 Aug;28(8):545-560
pubmed: 28647324
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1384-9
pubmed: 15677334
Nature. 2011 Apr 14;472(7342):230-3
pubmed: 21399626
Adipocyte. 2019 Dec;8(1):98-104
pubmed: 30848691
Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1166-72
pubmed: 17164435
Mol Cell Endocrinol. 2013 Feb 25;366(2):194-203
pubmed: 22750051
Diabetes. 2006 Aug;55(8):2180-91
pubmed: 16873680
Genes Dis. 2014 Sep;1(1):87-105
pubmed: 25401122
Mol Cell Biol. 2000 Feb;20(3):1008-20
pubmed: 10629058
ISRN Inflamm. 2013 Dec 22;2013:139239
pubmed: 24455420
Cell Metab. 2010 Jun 9;11(6):554-65
pubmed: 20519126
Trends Endocrinol Metab. 2009 Jan;20(1):16-24
pubmed: 19008118
Pharmacol Res. 2020 Feb;152:104602
pubmed: 31846761
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807
pubmed: 23388637
Nat Rev Mol Cell Biol. 2016 Aug;17(8):480-95
pubmed: 27251423
J Biol Chem. 2006 Sep 8;281(36):26602-14
pubmed: 16809344
J Biol Chem. 2007 Nov 9;282(45):32539-48
pubmed: 17728241
Insect Sci. 2015 Oct;22(5):587-96
pubmed: 25154865
J Agric Food Chem. 2012 Feb 1;60(4):955-63
pubmed: 22273148
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
Chem Biol. 2014 Jul 17;21(7):866-79
pubmed: 25036776
Mol Cell Biol. 2007 Jan;27(2):743-57
pubmed: 17060461
Diabetologia. 2012 Jan;55(1):245-54
pubmed: 21993711
PLoS One. 2019 May 17;14(5):e0217090
pubmed: 31100089
World J Stem Cells. 2014 Jan 26;6(1):33-42
pubmed: 24567786
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10703-8
pubmed: 17556545
Stem Cell Res Ther. 2013 Jul 09;4(4):79
pubmed: 23838354
J Biol Chem. 2001 Jul 27;276(30):28430-5
pubmed: 11375992
Ann Med. 2002;34(6):410-8
pubmed: 12523496
Cell Metab. 2011 Apr 6;13(4):376-388
pubmed: 21459323
J Cell Biol. 2003 Sep 1;162(5):899-908
pubmed: 12952940
Am J Physiol Endocrinol Metab. 2006 Jul;291(1):E175-81
pubmed: 16464908
Cell. 2012 May 11;149(4):871-85
pubmed: 22579288
Cell. 2014 Jan 16;156(1-2):304-16
pubmed: 24439384
J Biol Chem. 2002 Aug 23;277(34):30998-1004
pubmed: 12055200
Biochem J. 2019 Jun 26;476(12):1725-1740
pubmed: 31189568
Genes Dev. 1996 Nov 1;10(21):2794-804
pubmed: 8946919
PLoS One. 2014 Feb 14;9(2):e87894
pubmed: 24551069
J Cell Biochem. 2011 May;112(5):1364-75
pubmed: 21312243
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5379-84
pubmed: 16565215
J Endocrinol. 2019 Nov;243(2):R19-R27
pubmed: 31419785
Expert Opin Ther Targets. 2009 Aug;13(8):975-86
pubmed: 19534570
Cell. 2014 Jan 16;156(1-2):20-44
pubmed: 24439368
Nat Cell Biol. 2001 Mar;3(3):267-75
pubmed: 11231576
Diabetes. 2010 Mar;59(3):554-63
pubmed: 19934007
Endocrinology. 2011 Oct;152(10):3668-79
pubmed: 21862616
Mol Cell Biochem. 2013 May;377(1-2):35-44
pubmed: 23378049