Effect of small vessel disease burden and lacunes on gait/posture impairment in Parkinson's disease.
Cerebral small vessel disease
Gait
Lacunae
Parkinson’s disease
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
02
02
2020
accepted:
07
05
2020
pubmed:
28
5
2020
medline:
15
5
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
The comorbidity of cerebral small vessel disease (CSVD) may worsen gait impairment of Parkinson's disease (PD). However, the evidence remains scarce and controversial, and the mechanism of their potential interaction remains largely unknown. The present study aimed to investigate the overall impact of quantity and location of CSVD on gait/posture function in PD. This cross-sectional study included 315 consecutive eligible patients with PD from Beijing Tiantan Hospital from May 2016 to August 2018. Associations of gait/posture subscores with the burden score of CSVD and four CSVD imaging markers were assessed using multivariate linear regression models. Burden of CSVD was significantly associated with more severe gait/posture impairment in PD in the unadjusted model (β = 0.521, P = 0.011, 95% CI 0.118-0.923) and in the model adjusted for age, hypertension, ischemic stroke, low-density lipoprotein level, cholesterol level, and cognitive statues (β = 0.448, P = 0.047, 95% CI 0.006-0.891). The presence of lacunes, but not other CSVD markers, was significantly associated with higher gait/posture subscores after the adjustment (β = 0.492, P = 0.041, 95% CI 0.021-0.964), and the number of lacunes in the basal ganglia significantly correlated with the gait/posture subscores in patients with PD (P = 0.012, Spearman r = 0.161). CSVD and lacunes in the basal ganglia may independently contribute to gait/posture dysfunction in PD. Promoting neurovascular health may preserve some gait/posture function of PD.
Identifiants
pubmed: 32458249
doi: 10.1007/s10072-020-04452-z
pii: 10.1007/s10072-020-04452-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3617-3624Subventions
Organisme : National Natural Science Foundation of China
ID : 81771367, 81571226
Organisme : the Ministry of Science and Technology of the People's Republic of China
ID : 2017YFC1310203, 2016YFC1306501
Organisme : Beijing Municipal Science and Technology Commission
ID : Z171100000117013
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