Fetal-derived macrophages persist and sequentially maturate in ovaries after birth in mice.
Developmental origin
Macrophages
Mass cytometry
Monocytes
Ovaries
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
02
01
2020
revised:
19
03
2020
accepted:
25
05
2020
pubmed:
28
5
2020
medline:
12
1
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
Macrophages, which are highly diverse in different tissues, play a complex and vital role in tissue development, homeostasis, and inflammation. The origin and heterogeneity of tissue-resident monocytes and macrophages in ovaries remains unknown. Here we identify three tissue-resident monocyte populations and five macrophage populations in the adult ovaries using high-dimensional single cell mass cytometry. Ontogenic analyses using cell fate mapping models and cell depletion experiments revealed the infiltration of ovaries by both yolk sac and fetal liver-derived macrophages already during the embryonic development. Moreover, we found that both embryonic and bone marrow-derived macrophages contribute to the distinct ovarian macrophage subpopulations in the adults. These assays also showed that fetal-derived MHC II-negative macrophages differentiate postnatally in the maturing ovary to MHC II-positive cells. Our analyses further unraveled that the developmentally distinct macrophage types share overlapping distribution and scavenging function in the ovaries under homeostatic conditions. In conclusion, we report here the first comprehensive analyses of ovarian monocytes and macrophages. In addition, we show that the mechanisms controlling monocyte immigration, the phenotype of different pools of interstitial macrophages, and the interconversion capacity of fetal-derived macrophages in ovaries are remarkably different from those seen in other tissue niches.
Identifiants
pubmed: 32459864
doi: 10.1002/eji.202048531
doi:
Substances chimiques
Membrane Proteins
0
Plvap protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1500-1514Subventions
Organisme : Sigrid Juséliuksen Säätiö
Pays : International
Organisme : Syöpäsäätiö
Pays : International
Organisme : Academy of Finland
Pays : International
Organisme : Jane ja Aatos Erkon Säätiö
Pays : International
Informations de copyright
© 2020 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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