Post-translational Modifications of Opioid Receptors.
drug addiction
glycosylation
morphine
palmitoylation
phosphorylation
receptor desensitization
ubiquitination
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
13
12
2019
revised:
26
03
2020
accepted:
26
03
2020
entrez:
28
5
2020
pubmed:
28
5
2020
medline:
31
7
2021
Statut:
ppublish
Résumé
Post-translational modifications (PTMs) are key events in signal transduction since they affect protein function by regulating their abundance and/or activity. PTMs involve the covalent attachment of functional groups to specific amino acids. Since they tend to be generally reversible, PTMs serve as regulators of signal transduction pathways. G-protein-coupled receptors (GPCRs) are major signaling proteins that undergo multiple types of PTMs. In this Review, we focus on the opioid receptors, members of GPCR family A, and highlight recent advances in the field that have underscored the importance of PTMs in the functional regulation of these receptors. Since opioid receptor activity plays a central role in the development of tolerance and addiction to morphine and other drugs of abuse, understanding the molecular mechanisms regulating receptor activity is of fundamental importance.
Identifiants
pubmed: 32459993
pii: S0166-2236(20)30071-0
doi: 10.1016/j.tins.2020.03.011
pmc: PMC7323054
mid: NIHMS1585685
pii:
doi:
Substances chimiques
Receptors, Opioid
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
417-432Subventions
Organisme : NINDS NIH HHS
ID : R01 NS026880
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA008863
Pays : United States
Organisme : NIDA NIH HHS
ID : R44 DA035531
Pays : United States
Organisme : NIDA NIH HHS
ID : R56 DA008863
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Biochem J. 2016 Feb 15;473(4):497-508
pubmed: 26635353
Circ Res. 2007 Apr 27;100(8):1142-54
pubmed: 17463329
J Biol Chem. 2011 Sep 9;286(36):31731-41
pubmed: 21757712
J Biol Chem. 2008 Oct 24;283(43):29086-98
pubmed: 18703511
Mol Pharmacol. 2017 Sep;92(3):201-210
pubmed: 28246190
Mol Cell. 2009 Feb 13;33(3):275-86
pubmed: 19217402
J Cell Biol. 2007 Jan 29;176(3):249-54
pubmed: 17242068
Neuropsychopharmacology. 2015 Mar 13;40(5):1091-100
pubmed: 25336208
Sci Signal. 2019 Mar 26;12(574):
pubmed: 30914485
BMC Biol. 2012 Mar 19;10:27
pubmed: 22429402
Traffic. 2011 Feb;12(2):137-48
pubmed: 20854416
J Biol Chem. 2000 Nov 24;275(47):36659-64
pubmed: 10973976
J Biol Chem. 2001 Apr 13;276(15):12345-55
pubmed: 11152677
Mol Pharmacol. 2019 Dec;96(6):702-710
pubmed: 31575621
Front Synaptic Neurosci. 2019 Aug 29;11:25
pubmed: 31555119
Mol Psychiatry. 2004 Jan;9(1):99-108
pubmed: 14699447
Cell Signal. 2018 Jan;42:184-193
pubmed: 29097258
J Neurosci. 2011 Sep 28;31(39):13890-6
pubmed: 21957251
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1193
pubmed: 8302853
Biochemistry. 2000 May 9;39(18):5492-9
pubmed: 10820022
Cell. 2017 Nov 16;171(5):1165-1175.e13
pubmed: 29149605
Mol Pharmacol. 2015 Oct;88(4):816-24
pubmed: 25934731
Mol Pharmacol. 2006 Apr;69(4):1083-94
pubmed: 16339847
J Biol Chem. 2004 Jan 16;279(3):1810-8
pubmed: 14597630
Crit Rev Biotechnol. 2018 Sep;38(6):851-867
pubmed: 29262720
Cell Signal. 2007 Dec;19(12):2558-71
pubmed: 17825524
Cell Rep. 2016 Sep 6;16(10):2686-2698
pubmed: 27568556
Mol Pharmacol. 2012 Nov;82(5):983-92
pubmed: 22914548
BMC Cell Biol. 2012 Mar 19;13:6
pubmed: 22429589
Proteomes. 2018 Oct 06;6(4):
pubmed: 30301203
J Pain. 2005 Mar;6(3):159-67
pubmed: 15772909
J Neurochem. 1999 Oct;73(4):1502-9
pubmed: 10501195
Mol Pharmacol. 2015 Oct;88(4):814-5
pubmed: 26152197
PLoS One. 2012;7(3):e34192
pubmed: 22457824
Pharmacol Rev. 2013 Jan 15;65(1):223-54
pubmed: 23321159
Mol Psychiatry. 2020 Jul;25(7):1406-1419
pubmed: 31481756
Neuroscience. 2005;135(2):305-13
pubmed: 16112476
Mol Pharmacol. 2017 Nov;92(5):588-600
pubmed: 28893975
Trends Pharmacol Sci. 2013 Jan;34(1):6-12
pubmed: 23127545
Front Mol Neurosci. 2019 May 01;12:104
pubmed: 31118885
Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G79-G89
pubmed: 31091149
Trends Pharmacol Sci. 2008 Oct;29(10):528-35
pubmed: 18760490
Mol Pharmacol. 1993 Oct;44(4):749-56
pubmed: 8232225
J Biol Chem. 2007 Aug 3;282(31):22315-23
pubmed: 17565992
Mol Pharmacol. 2015 Oct;88(4):825-35
pubmed: 25969388
Prog Mol Biol Transl Sci. 2015;132:15-38
pubmed: 26055053
Biol Psychiatry. 2014 Nov 15;76(10):767-74
pubmed: 24629717
J Biol Chem. 2012 Dec 7;287(50):42019-30
pubmed: 23086955
J Neurosci. 2009 Mar 18;29(11):3551-64
pubmed: 19295160
Cell Signal. 2010 Apr;22(4):684-96
pubmed: 20043990
J Neurophysiol. 2007 Feb;97(2):1058-67
pubmed: 17151221
Mol Pharmacol. 2019 Oct;96(4):505-514
pubmed: 31383769
Biochem Pharmacol. 2002 Jul 15;64(2):257-66
pubmed: 12123746
Dev Cell. 2012 Sep 11;23(3):519-32
pubmed: 22940114
Biochem J. 2012 Jan 1;441(1):379-86
pubmed: 21864297
Mol Pharmacol. 2010 Oct;78(4):756-66
pubmed: 20647394
EMBO J. 2004 Aug 18;23(16):3282-9
pubmed: 15272312
J Biol Chem. 2005 Sep 23;280(38):32618-24
pubmed: 16046395
Br J Pharmacol. 2014 Mar;171(5):1330-40
pubmed: 24308893
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13
pubmed: 9689128
J Biol Chem. 1993 Dec 15;268(35):26447-51
pubmed: 8253772
Biochemistry. 2007 Sep 25;46(38):10960-70
pubmed: 17711303
Prog Mol Biol Transl Sci. 2016;141:1-55
pubmed: 27378754
Br J Pharmacol. 2012 Mar;165(6):1717-1736
pubmed: 21699508
Nat Chem Biol. 2006 Nov;2(11):584-90
pubmed: 17051234
FEBS Lett. 2015 Aug 19;589(18):2401-8
pubmed: 26226422
Pharmacol Rev. 2019 Apr;71(2):267-315
pubmed: 30914442
J Neurosci. 2002 Dec 1;22(23):10494-500
pubmed: 12451149
Mol Pharmacol. 2001 Jun;59(6):1360-8
pubmed: 11353794
EMBO Rep. 2008 Jun;9(6):536-42
pubmed: 18516089
Nature. 2000 Dec 7;408(6813):720-3
pubmed: 11130073
Elife. 2018 Mar 28;7:
pubmed: 29589831
J Med Chem. 2016 Aug 11;59(15):7011-28
pubmed: 26878436
Int J Mol Sci. 2017 Apr 27;18(5):
pubmed: 28448471
Br J Pharmacol. 2015 Jan;172(2):317-23
pubmed: 24528283
Nat Rev Neurosci. 2018 Aug;19(8):499-514
pubmed: 29934561
Br J Pharmacol. 2012 Nov;167(6):1259-70
pubmed: 22725608
Biochem Biophys Res Commun. 2008 Jan 4;365(1):82-8
pubmed: 17980152
Science. 2007 Nov 23;318(5854):1258-65
pubmed: 17962520
Br J Pharmacol. 2004 Jan;141(1):55-64
pubmed: 14662727
Mol Pharmacol. 2008 Apr;73(4):1319-30
pubmed: 18212250
Neuropsychopharmacology. 2018 Jun;43(7):1530-1538
pubmed: 29497164
Acta Anaesthesiol Scand. 2004 Nov;48(10):1232-9
pubmed: 15504181
Anesthesiology. 2011 Nov;115(5):1054-62
pubmed: 21926562
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16045-50
pubmed: 18836069
Front Biosci. 2004 May 01;9:1665-79
pubmed: 14977578
J Pharmacol Exp Ther. 2010 Mar;332(3):1127-35
pubmed: 20008489
Cell. 2006 Sep 8;126(5):855-67
pubmed: 16959566
Biotechnol Adv. 2013 Jan-Feb;31(1):17-37
pubmed: 22484115
J Biol Chem. 2009 Jan 23;284(4):1990-2000
pubmed: 19029294
J Biol Chem. 2001 Apr 20;276(16):12774-80
pubmed: 11278523
Exp Neurol. 1986 Aug;93(2):348-58
pubmed: 3015659
J Biol Chem. 2000 May 5;275(18):13727-36
pubmed: 10788493
Nat Commun. 2018 Mar 13;9(1):1050
pubmed: 29535304
Mol Pharmacol. 2019 Jan;95(1):11-19
pubmed: 30348895
J Physiol Pharmacol. 2010 Jun;61(3):355-62
pubmed: 20610867
J Neurosci. 2016 Oct 5;36(40):10392-10403
pubmed: 27707973
Glycobiology. 2002 Apr;12(4):43R-56R
pubmed: 12042244
Mol Pharmacol. 2011 Apr;79(4):768-75
pubmed: 21212139
Sci Signal. 2016 Feb 09;9(414):ra16
pubmed: 26861044
J Biol Chem. 2001 Feb 16;276(7):4709-16
pubmed: 11085981
Mol Pharmacol. 1996 Oct;50(4):985-93
pubmed: 8863845
J Biol Chem. 2011 Nov 18;286(46):40193-204
pubmed: 21953467
Pain. 2016 Apr;157(4):910-921
pubmed: 26713421
Nat Commun. 2019 Jan 21;10(1):367
pubmed: 30664663
Sci Signal. 2011 Aug 9;4(185):ra52
pubmed: 21868358
Traffic. 2019 Feb;20(2):110-120
pubmed: 30426616
Sci Signal. 2018 Jul 17;11(539):
pubmed: 30018083
Cell Signal. 2005 Dec;17(12):1457-65
pubmed: 16014327
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15487-92
pubmed: 18832151
Br J Pharmacol. 2011 Sep;164(2):298-307
pubmed: 21449911
J Cell Physiol. 2016 Oct;231(10):2071-80
pubmed: 26790995
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Trends Biochem Sci. 2018 Apr;43(4):269-284
pubmed: 29506880
Mol Pharmacol. 2015 Aug;88(2):347-56
pubmed: 26013542
Brain Res. 2007 Jul 23;1159:86-93
pubmed: 17582387
FEBS Lett. 1998 Dec 11;441(1):148-52
pubmed: 9877183
Nat Rev Mol Cell Biol. 2007 Jul;8(7):530-41
pubmed: 17585314
Neuropharmacology. 2018 Mar 15;131:238-255
pubmed: 29273520
Front Pharmacol. 2019 Feb 19;10:125
pubmed: 30837883
Mol Pharmacol. 2013 Mar;83(3):633-9
pubmed: 23239825
Trends Pharmacol Sci. 2004 Jan;25(1):35-41
pubmed: 14723977
Pharmacol Ther. 2003 Jan;97(1):1-33
pubmed: 12493533
J Pharmacol Exp Ther. 1997 Jul;282(1):355-62
pubmed: 9223574
Biochem Biophys Res Commun. 1997 Nov 17;240(2):304-8
pubmed: 9388473
EMBO J. 2003 Feb 17;22(4):826-32
pubmed: 12574119
J Neurochem. 2013 Jan;124(2):189-99
pubmed: 23106126
J Neurochem. 1997 Oct;69(4):1767-70
pubmed: 9326307
Acta Anaesthesiol Scand. 2006 Aug;50(7):787-92
pubmed: 16879459
Biochem Pharmacol. 2007 Feb 15;73(4):534-49
pubmed: 17141202
Mol Pharmacol. 2009 Jun;75(6):1307-16
pubmed: 19289571
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7157-62
pubmed: 9618555
Biochem Pharmacol. 1985 Jan 1;34(1):9-17
pubmed: 2981531
Mol Endocrinol. 2013 Apr;27(4):558-72
pubmed: 23471539
Neuron. 2011 Jan 13;69(1):120-31
pubmed: 21220103
Mol Pharmacol. 2000 Oct;58(4):795-801
pubmed: 10999950
J Pharmacol Exp Ther. 2000 Dec;295(3):1094-100
pubmed: 11082445
J Biol Chem. 2001 Feb 9;276(6):4416-23
pubmed: 11054417
J Biol Chem. 2001 Feb 2;276(5):3130-7
pubmed: 11067846
J Biol Chem. 2006 Jun 9;281(23):15780-9
pubmed: 16595649
Br J Pharmacol. 2015 Jan;172(2):583-92
pubmed: 24697621
Cell Rep. 2015 Mar 24;10(11):1925-36
pubmed: 25801029
Mol Pharmacol. 1995 Apr;47(4):738-44
pubmed: 7723734
Br J Pharmacol. 2009 Sep;158(1):154-6
pubmed: 19719778
Mol Pharmacol. 2000 Nov;58(5):1050-6
pubmed: 11040053
J Biol Chem. 2012 Jul 6;287(28):23407-17
pubmed: 22610096
Mol Biotechnol. 2004 Nov;28(3):241-55
pubmed: 15542924
Trends Neurosci. 2013 Mar;36(3):195-206
pubmed: 23219016
Annu Rev Biochem. 1998;67:425-79
pubmed: 9759494
J Biol Chem. 2009 Jul 3;284(27):18357-67
pubmed: 19416973
Curr Biol. 2013 May 20;23(10):R431-5
pubmed: 23701681
J Biol Chem. 2014 Jun 20;289(25):17830-42
pubmed: 24798333
Science. 1986 Aug 15;233(4765):774-6
pubmed: 3016896