The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of Dirofilaria immitis in cats.
Cat
Dirofilaria immitis
Heartworm
Macrocyclic Lactone
Prevention
Resistance
Sarolaner
Selamectin
Journal
Veterinary parasitology
ISSN: 1873-2550
Titre abrégé: Vet Parasitol
Pays: Netherlands
ID NLM: 7602745
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
09
01
2020
revised:
17
04
2020
accepted:
21
04
2020
pubmed:
28
5
2020
medline:
25
3
2021
entrez:
28
5
2020
Statut:
ppublish
Résumé
Revolution®/Stronghold® Plus, a topical endectocide incorporating 6 mg/kg selamectin plus 1 mg/kg sarolaner, is approved for use in cats to prevent heartworm disease. The efficacy of selamectin has not previously been evaluated against any macrocyclic lactone (ML)-resistant heartworm strains in cats for prevention of heartworm disease. In this study, an experimental combination formulation of selamectin (6 mg/kg) plus sarolaner (2 mg/kg) was assessed for preventing the development of a ML-resistant strain of Dirofilaria immitis in cats. Forty purpose-bred domestic shorted-haired cats (20 males; 20 females) from 7-9 months of age and negative for heartworm antigen prior to study inclusion were used. On Day -30, cats were inoculated with 100 D. immitis L
Identifiants
pubmed: 32460111
pii: S0304-4017(20)30102-3
doi: 10.1016/j.vetpar.2020.109122
pii:
doi:
Substances chimiques
Antinematodal Agents
0
Azetidines
0
Spiro Compounds
0
sarolaner
0
Ivermectin
70288-86-7
selamectin
A2669OWX9N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109122Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.