Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.
RTX toxin
acylation
acyltransferase
adenylate cyclase toxin (CyaA)
bacterial toxin
cytotoxicity
cytotoxin (RtxA)
fatty acid
fatty acyl
posttranslational modification
protein acylation
protein translocation
protoxin
α-hemolysin (HlyA)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
29
04
2020
revised:
20
05
2020
pubmed:
29
5
2020
medline:
14
1
2021
entrez:
29
5
2020
Statut:
ppublish
Résumé
In a wide range of organisms, from bacteria to humans, numerous proteins have to be posttranslationally acylated to become biologically active. Bacterial
Identifiants
pubmed: 32461253
pii: S0021-9258(17)48951-4
doi: 10.1074/jbc.RA120.014122
pmc: PMC7363117
doi:
Substances chimiques
Bacterial Proteins
0
Fatty Acids
0
Hemolysin Proteins
0
Acyltransferases
EC 2.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9268-9280Informations de copyright
© 2020 Osickova et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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