Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?

Adult Biomarkers Blast Injuries / blood Brain Concussion / blood Cross-Sectional Studies Depression / blood Exosomes / chemistry Female Follow-Up Studies Humans Interleukin-6 / blood Male Middle Aged Neurofilament Proteins / blood Post-Concussion Syndrome / blood Prognosis Retrograde Degeneration Severity of Illness Index Stress Disorders, Post-Traumatic / blood Tumor Necrosis Factor-alpha / analysis Vascular Endothelial Growth Factor A / blood Veterans Veterans Health Warfare

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
09 06 2020
Historique:
received: 22 07 2019
accepted: 02 12 2019
pubmed: 29 5 2020
medline: 25 9 2020
entrez: 29 5 2020
Statut: ppublish

Résumé

To measure exosomal and plasma levels of candidate blood biomarkers in veterans with history of mild traumatic brain injury (mTBI) and test their relationship with chronic symptoms. Exosomal and plasma levels of neurofilament light (NfL) chain, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and vascular endothelial growth factor (VEGF) were measured using an ultrasensitive assay in a cohort of 195 veterans, enrolled in the Chronic Effects of Neurotrauma Consortium Longitudinal Study. We examined relationships between candidate biomarkers and symptoms of postconcussive syndrome (PCS), posttraumatic stress disorder (PTSD), and depression. Biomarker levels were compared among those with no traumatic brain injury (TBI) (controls), 1-2 mTBIs, and repetitive (3 or more) mTBIs. Elevated exosomal and plasma levels of NfL were associated with repetitive mTBIs and with chronic PCS, PTSD, and depression symptoms. Plasma TNF-α levels correlated with PCS and PTSD symptoms. The total number of mTBIs correlated with exosomal and plasma NfL levels and plasma IL-6. Increased number of years since the most recent TBI correlated with higher exosomal NfL and lower plasma IL-6 levels, while increased number of years since first TBI correlated with higher levels of exosomal and plasma NfL, as well as plasma TNF-α and VEGF. Repetitive mTBIs are associated with elevated exosomal and plasma levels of NfL, even years following these injuries, with the greatest elevations in those with chronic PCS, PTSD, and depression symptoms. Our results suggest a possible neuroinflammatory and axonal disruptive basis for symptoms that persist years after mTBI, especially repetitive.

Identifiants

DOI: 10.1212/WNL.0000000000009577 PMID: 32461282 PMC: PMC7455370
pubmed: 32461282
pii: WNL.0000000000009577
doi: 10.1212/WNL.0000000000009577
pmc: PMC7455370
doi:

Substances chimiques

Biomarkers 0
IL6 protein, human 0
Interleukin-6 0
Neurofilament Proteins 0
Tumor Necrosis Factor-alpha 0
VEGFA protein, human 0
Vascular Endothelial Growth Factor A 0
neurofilament protein L 0

Types de publication

Journal Article Multicenter Study Observational Study Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2412-e2423

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2020 American Academy of Neurology.

Références

Handb Clin Neurol. 2015;127:45-66
pubmed: 25702209
J Head Trauma Rehabil. 2020 Jan/Feb;35(1):66-73
pubmed: 31033745
JAMA Neurol. 2016 Nov 01;73(11):1308-1315
pubmed: 27654934
J Head Trauma Rehabil. 2014 Jan-Feb;29(1):1-10
pubmed: 23474880
Front Immunol. 2016 Dec 05;7:556
pubmed: 27994591
Mol Cell Neurosci. 2015 May;66(Pt B):75-80
pubmed: 25748121
Neurology. 2017 May 9;88(19):1788-1794
pubmed: 28404801
Lancet Psychiatry. 2016 Dec;3(12):1166-1175
pubmed: 27889010
J Inflamm Res. 2018 Mar 22;11:111-121
pubmed: 29606885
Neurology. 2018 Oct 9;91(15):e1385-e1389
pubmed: 30209234
Exp Neurol. 2009 Dec;220(2):400-3
pubmed: 19733172
Depress Anxiety. 2011 Jul;28(7):596-606
pubmed: 21681864
JAMA Neurol. 2014 Jun;71(6):684-92
pubmed: 24627036
Lancet Psychiatry. 2015 Nov;2(11):1002-12
pubmed: 26544749
Front Neurol. 2018 Dec 19;9:1113
pubmed: 30619066
Cardiovasc Res. 2010 Jul 15;87(2):262-71
pubmed: 20400620
Cell Transplant. 2017 Jul;26(7):1169-1177
pubmed: 28933225
Brain Behav Immun. 2014 Nov;42:81-8
pubmed: 24929195
Biol Psychiatry. 2008 Sep 15;64(6):484-90
pubmed: 18514163
Br J Sports Med. 2017 Jun;51(12):969-977
pubmed: 28455362
Cytokine Growth Factor Rev. 2014 Feb;25(1):1-19
pubmed: 24332926
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Apr 20;91:103-112
pubmed: 29932946
JAMA Pediatr. 2016 Jul 1;170(7):647-53
pubmed: 27135397
J Clin Exp Neuropsychol. 2015;37(3):325-37
pubmed: 25849968
Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652):
pubmed: 25135964
Psychoneuroendocrinology. 2015 Jan;51:557-66
pubmed: 25465168
Biol Psychiatry. 1999 Apr 1;45(7):833-9
pubmed: 10202570
Nat Rev Neurosci. 2008 Jan;9(1):46-56
pubmed: 18073775
Cell Transplant. 2017 Jul;26(7):1131-1155
pubmed: 28933213
Neuron. 2012 Dec 6;76(5):886-99
pubmed: 23217738
Brain Sci. 2017 Jul 09;7(7):
pubmed: 28698487
Ann Clin Transl Neurol. 2016 Jul 01;3(8):623-36
pubmed: 27606344
J Neurotrauma. 2016 Oct 1;33(19):1784-1789
pubmed: 26700106
JAMA Neurol. 2017 Jul 1;74(7):821-829
pubmed: 28459953
Neurosurgery. 2005 Oct;57(4):719-26; discussion 719-26
pubmed: 16239884
J Neurotrauma. 2018 Oct 15;35(20):2351-2356
pubmed: 29609512
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Brain Inj. 2016;30(12):1469-1480
pubmed: 27834538
Ann Clin Transl Neurol. 2015 Jul;2(7):748-55
pubmed: 26273687
Cytokine. 2018 Oct;110:248-256
pubmed: 29396048

Auteurs

Vivian A Guedes (VA)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.
ORCID: 0000-0001-8478-2465

Kimbra Kenney (K)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia. kimbra.kenney@usuhs.edu.

Pashtun Shahim (P)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Bao-Xi Qu (BX)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Chen Lai (C)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Christina Devoto (C)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

William C Walker (WC)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Tracy Nolen (T)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Ramon Diaz-Arrastia (R)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

Jessica M Gill (JM)

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Plaies et blessures › Barotraumatismes › Traumatismes par explosion › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Plaies et blessures › Plaies non pénétrantes › Traumatismes crâniens fermés › Commotion de l'encéphale › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Exosomes › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines neurofilamenteuses › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Plaies et blessures › Plaies non pénétrantes › Traumatismes crâniens fermés › Commotion de l'encéphale › Syndrome post-commotionnel › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Diagnostic › Pronostic › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dégénérescence nerveuse › Dégénérescence rétrograde › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Exosomal neurofilament light: A prognostic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › Exosomal neurofilament light: A prognostic...
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